DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PpD3 and SPBC3F6.01c

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_596740.1	Gene:	SPBC3F6.01c / 2541004	PomBaseID:	SPBC3F6.01c	Length:	473	Species:	Schizosaccharomyces pombe

Alignment Length:	471	Identity:	231/471 - (49%)
Similarity:	326/471 - (69%)	Gaps:	6/471 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 AEQYKNQGNEMLKTKEFSKAIDMYTKAIELHPNSAIYYANRSLAHLRQESFGFALQDGVSAVKAD 113
            |.:.||:.|:.||.....:|||:|||||||...:||.|:|||||||:.|.:|.|:.|...|::.|
pombe     5 ALELKNEANKFLKEGHIVQAIDLYTKAIELDSTNAILYSNRSLAHLKSEDYGLAINDASKAIECD 69

  Fly   114 PAYLKGYYRRAAAHMSLGKFKQALCDFEFVAKCRPNDKDAKLKFTECNKIVKMRAFERAIAVDKP 178
            |.|.|.|:|||.||:::.:.|:|:.||.......|:|..|:.|..||.::||...|:.||...:|
pombe    70 PEYAKAYFRRATAHIAIFQPKEAVGDFRKALALAPSDPAARKKLRECEQLVKRIRFQEAIHNTEP 134

  Fly   179 EKTLSEMYSDMENITIEDDYKGPQLEDGKVTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMR 243
            ...|:.:  ::|::.|..||.|..||. ::|.:|::::.|.:...|:|..||||.||.::...:.
pombe   135 PSPLANI--NIEDMDIPSDYDGVILEK-QITKEFVEDMKERFCQGKKLPLKFAYSILRDLKELLE 196

  Fly   244 AQPSLVDITVPDEEKFTICGDIHGQFYDLMNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTL 308
            ..|||:||.|..:|...||||.|||::||:|||:::|.||..|.||||||||||||:|.|..|||
pombe   197 KTPSLIDIPVKGDETLVICGDTHGQYFDLLNIFKLHGPPSPTNKYLFNGDFVDRGSWSTEVAFTL 261

  Fly   309 FGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVM 373
            :.:|||||:..|:.|||||:.:||::|||.||..:||.....:||::.|:.|||...|:...||:
pombe   262 YAYKLLYPDAVFINRGNHETDDMNKVYGFEGECRSKYNERTFNIFSETFSLLPLGSLISDSYLVV 326

  Fly   374 HGGLFSTEDVTLDHIRRIER--NCQPPEEGLMCELLWSDPQQWMGLGQSKRGVGIQFGPDVTEKF 436
            ||||||.::||||.:|.|:|  ..||.:.|||.|:||:|||...|.|.||||||:||||||:::|
pombe   327 HGGLFSDDNVTLDQLRNIDRFSKKQPGQSGLMMEMLWTDPQPAPGRGPSKRGVGLQFGPDVSKRF 391

  Fly   437 CKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNNLKPNYKSFEAV 501
            |:.|.|..:||||||:|.||||.|:|.||||||||||||:.||:||.|.:. .:::.::..||||
pombe   392 CEANGLKAVIRSHEVRDQGYEVEHDGYCITVFSAPNYCDSTGNLGAVIKVK-EDMELDFHQFEAV 455

  Fly   502 PHPDVKPMAYANSLMN 517
            |||:::||||||.|::
pombe   456 PHPNIRPMAYANGLLS 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150	31/64 (48%)
		TPR_1	49..81	CDD:278916	16/31 (52%)
		TPR repeat	49..77	CDD:276809	13/27 (48%)
		TPR repeat	82..112	CDD:276809	15/29 (52%)
		MPP_PP5_C	198..513	CDD:277362	167/316 (53%)
		PP2Ac	226..502	CDD:197547	151/277 (55%)
SPBC3F6.01c	NP_596740.1	TPR_11	4..70	CDD:290150	31/64 (48%)
		TPR repeat	5..33	CDD:276809	13/27 (48%)
		TPR_11	38..104	CDD:290150	29/65 (45%)
		TPR repeat	38..68	CDD:276809	15/29 (52%)
		TPR_2	73..106	CDD:285020	12/32 (38%)
		TPR repeat	73..101	CDD:276809	11/27 (41%)
		MPP_PP5_C	152..467	CDD:277362	167/316 (53%)
		PP2Ac	184..456	CDD:197547	148/272 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	233	1.000	Domainoid score	I489
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4550
Inparanoid	1	1.050	467	1.000	Inparanoid score	I276
OMA	1	1.010	-	-		QHG54071
OrthoFinder	1	1.000	-	-		FOG0005066
OrthoInspector	1	1.000	-	-		oto101755
orthoMCL	1	0.900	-	-		OOG6_102598
Panther	1	1.100	-	-	LDO	PTHR45668
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R977
SonicParanoid	1	1.000	-	-		X3586
TreeFam	1	0.960	-	-
	14	13.860