DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PpD3 and Ppef1

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_011246120.1	Gene:	Ppef1 / 237178	MGIID:	1097157	Length:	676	Species:	Mus musculus

Alignment Length:	514	Identity:	159/514 - (30%)
Similarity:	243/514 - (47%)	Gaps:	92/514 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 QGNEMLK--TKEFSKAIDMYTKAI-------ELHPNSAIYYAN---RSLAHLR-QESFGFALQDG 106
            :||:..|  |.....:|::.|.|.       :|...:|:...|   |..|.|| ::.:..|:...
Mouse     9 KGNKSKKENTDIIMSSINLVTSASFITEHSRDLMIKAALVIQNWYRRYRARLRVRQHYALAIFQS 73

  Fly   107 VSAVKADPAYLKGYYRRAAAHMSLGKFKQALCDFEFVAK--CRPNDKDAKLKFTECNKIVKMRAF 169
            :.            |......|.|..|      |.|:.:  .:.|::|:.|         ..|.|
Mouse    74 IE------------YSDEQGQMQLSSF------FSFMLENYTKTNNEDSAL---------VTRIF 111

  Fly   170 ERAIAVDKPEKTLSEMYSDMENITIEDDYKGPQLEDGKVTLKFMKELMEHYKAQKRLHRKFAYKI 234
            :..    :.|..:.:....:..|.:.|.|.||:|: ..:|...:..|::.:|.|:.||..:..::
Mouse   112 DNT----RRESQIKDRDDFLGLIEVPDSYDGPRLQ-FPLTFTDIHILLQAFKQQQILHAHYVLEV 171

  Fly   235 LCEIDTYMRAQPSLVDITVPDEEKFTICGDIHGQFYDLMNIFEINGLPSEKNPYLFNGDFVDRGS 299
            |.|....::..|:...:.....::.|||||:||:..|||.||..||||||.|||:|||||||||:
Mouse   172 LFEARKVLKQMPNFSHVKTFPAKEITICGDLHGKLDDLMLIFYKNGLPSENNPYVFNGDFVDRGN 236

  Fly   300 FSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYT---SAMADIFTQVFNWLP 361
            .|:|.:..|....|:||:...|.|||||...||..||||.|:..||.   ..:..:..:|:.|||
Mouse   237 NSMEILMILLVCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLP 301

  Fly   362 LCHCINQKILVMHGGLFSTEDV-TLDHIRR----------------------------IE-RNCQ 396
            :...|:.:|||:|||:..:.|: ||..::|                            :| |..:
Mouse   302 IGTIIDNEILVIHGGISESTDLNTLHQLQRNKMKSVLMPPVLGNQETGEKRNKSASNYVEPRKVE 366

  Fly   397 P---PEEGL-------MCELLWSDPQQWMG-LGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHE 450
            |   |.|.|       :.::|||||:...| ...:.||.|..||||||.|....|.|..:|||||
Mouse   367 PDKTPSEDLTKQEWEQIVDILWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLSKNQLKMLIRSHE 431

  Fly   451 VKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNNLKPNYKSFEAVPHPDVKPM 509
            .|..||||:|:||.||||||.||.:...|.||:|.::...: |.:..::......:.|:
Mouse   432 CKPDGYEVSHDGKVITVFSASNYYEEGSNRGAYIRLSYGTM-PQFFQYQVTSTSCLNPL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150	15/71 (21%)
		TPR_1	49..81	CDD:278916	8/34 (24%)
		TPR repeat	49..77	CDD:276809	7/30 (23%)
		TPR repeat	82..112	CDD:276809	7/33 (21%)
		MPP_PP5_C	198..513	CDD:277362	130/356 (37%)
		PP2Ac	226..502	CDD:197547	121/319 (38%)
Ppef1	XP_011246120.1	MPP_RdgC	144..479	CDD:277364	125/335 (37%)
		PTZ00183	518..660	CDD:185503
		EF-hand_7	595..663	CDD:372618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D215218at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820