DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and Y69E1A.4

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_502041.1	Gene:	Y69E1A.4 / 190550	WormBaseID:	WBGene00013476	Length:	375	Species:	Caenorhabditis elegans

Alignment Length:	364	Identity:	109/364 - (29%)
Similarity:	159/364 - (43%)	Gaps:	85/364 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 MENITIEDDYKGPQLEDGKVTLKFMKELMEHYKAQKRLHRKFAYKILCEID---------TYMRA 244
            ||.|..||.         |....|:.:::|  |...:...|.:..:.|..:         ..:.:
Worm     1 MEKINTEDQ---------KNVRNFVNKILE--KIVFKWTHKTSMDLFCAAELAELCHRARELIWS 54

  Fly   245 QPSLVDITVPDEEKFTIC--GDIHGQFYDLMNIFEINGLP------------------SEKNP-- 287
            :|..:.:..|      ||  |||||||.||:.:.::||.|                  :.|.|
Worm    55 EPIFLKLEAP------ICVMGDIHGQFDDLLAMLDMNGWPLSSQEFEALKDTTVRSRETGKRPQS 113

  Fly   288 ---------------------------------YLFNGDFVDRGSFSVECIFTLFGFKLLYPNHF 319
                                             |||.||:||||.||:|.:..|...||.||:..
Worm   114 EPHSTQPESSNDVKPPVAAPKSVNKEVTTGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRI 178

  Fly   320 FLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVT 384
            :|.||||||.::|..|||..||..:|.:.:.:.|..:||..|.|..||..|:.||||:  :|.:|
Worm   179 YLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGI--SEHLT 241

  Fly   385 -LDHIRRIERNCQPPEEGLMCELLWSDPQQW-MGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIR 447
             .:.....:|..:.|:.|::.:|.|:||... .|...|.||....|||.....|.|..:|..:||
Worm   242 SFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIR 306

  Fly   448 SHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITI 486
            .|:|.:.|||.....:.:|:|||||||....|..|..:|
Worm   307 GHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFSI 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	104/355 (29%)
		PP2Ac	226..502	CDD:197547	100/327 (31%)
Y69E1A.4	NP_502041.1	PP2Ac	36..360	CDD:197547	99/318 (31%)
Y69E1A.4	NP_502041.1	MPP_superfamily	39..358	CDD:301300	98/315 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900