DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and Y40H4A.2

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_506609.2	Gene:	Y40H4A.2 / 189799	WormBaseID:	WBGene00012741	Length:	333	Species:	Caenorhabditis elegans

Alignment Length:	356	Identity:	124/356 - (34%)
Similarity:	167/356 - (46%)	Gaps:	69/356 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 MYSDMENITIEDDYKGPQLEDGKVTLK-FMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSL 248
            |..:.|.:..::|.:..|  :....|| |:..||.....:|                    .|:.
Worm     1 MIQESERVDQDEDSENDQ--ERVAYLKAFISRLMTAPMKEK--------------------SPAE 43

  Fly   249 VDITVPDEE-------------KFT-------------ICGDIHGQFYDLMNIFEINGLPSEKNP 287
            ||:||..||             .|:             |.||:||.|.||..||.|:|.|...:
Worm    44 VDVTVSKEEIRIISNYAAASFGSFSTLMRVDEDCLPVHIVGDLHGHFGDLRRIFGIHGAPGISH- 107

  Fly   288 YLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKY----TSA 348
            |:|.||:||||...:|.:..|..:..|||:|.||.|||||..|....|||..|...||    |.|
Worm   108 YVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKGTLA 172

  Fly   349 MADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQ 413
            ...|. ..||.|||...|..|:|.||||: |.....|:.|.:|:|....|..||.|:|:||||::
Worm   173 WLHII-NAFNHLPLAALILDKVLCMHGGI-SPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEK 235

  Fly   414 WMGLGQSKRGVGIQFG-PDVT-EKFCKDNNLDYIIRSHEVKDM----GYEVAHNGKCITVFSAPN 472
            ...:|.|....||.|. .|:| ||||:||.||.|:|:|::...    |::...||:.:|:|||.|
Worm   236 TSNVGWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQISSEMIRGGHKWHANGRMVTIFSAAN 300

  Fly   473 YCDTMGNMGAFITITGNN------LKPNYKS 497
            |. :|||....|.|....      |:|..||
Worm   301 YL-SMGNDSCVIRIDEQKTMQFCLLRPVKKS 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	121/343 (35%)
		PP2Ac	226..502	CDD:197547	114/314 (36%)
Y40H4A.2	NP_506609.2	PP2Ac	49..328	CDD:197547	107/282 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900