DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and R08A2.2

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_506632.2	Gene:	R08A2.2 / 187692	WormBaseID:	WBGene00011133	Length:	371	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	116/358 - (32%)
Similarity:	167/358 - (46%)	Gaps:	67/358 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 IEDDYKGPQLEDGKVTLKFMKELMEH---YKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPD 255
            |.:..|| .|.:|:...:..|.::||   :......:.|..|.||.:.::.:...|:::.:
Worm     2 IMESQKG-DLYEGESVDQLAKRMIEHLLKWGVTDAFNDKQIYTILEKAESTLNPLPAMLQV---- 61

  Fly   256 EEKFTICGDIHGQFYDLMNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFF 320
            |...||.||||||...|:..|:..|.| .|..:||.||:||||:.|.|....||.:|:.||:...
Worm    62 EHPITIVGDIHGQLDALIRYFDAVGYP-PKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVH 125

  Fly   321 LARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTL 385
            |.|||||.:.||::|||..|:..|....|...:..|||.||||..:.|:||.||||
Worm   126 LLRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGG--------- 181

  Fly   386 DHIRRIERNCQPPE---------------EGLMCELLWSDPQQ----WMGLGQSKRGVGIQFGPD 431
                 |.:||...|               |||..:|:|:||.|    ...:.: :|.:.:.||..
Worm   182 -----ISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQDKCNTFAMNK-QRAISVVFGEK 240

  Fly   432 VTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNN------ 490
            ..:.|.|...|..|:|:|||...|:....|.||:||||||.||....|.||.:.::.:.
Worm   241 GLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTV 305

  Fly   491 LKP-----------------NYKSFE-AVPHPD 505
            |:|                 |||... |.|.|:
Worm   306 LRPRMIATPENIEIVKLMENNYKGLRVASPDPN 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	115/354 (32%)
		PP2Ac	226..502	CDD:197547	106/318 (33%)
R08A2.2	NP_506632.2	PP2Ac	36..308	CDD:197547	101/291 (35%)
R08A2.2	NP_506632.2	MPP_PPP_family	66..295	CDD:277316	94/244 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900