DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and F23B12.1

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_506574.3	Gene:	F23B12.1 / 184887	WormBaseID:	WBGene00009079	Length:	329	Species:	Caenorhabditis elegans

Alignment Length:	326	Identity:	124/326 - (38%)
Similarity:	186/326 - (57%)	Gaps:	13/326 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 YSDMENITIEDDYKGPQLEDGKVTLKFMKELMEHYK--AQKRLHRKFAYKILCEIDTYMRAQPSL 248
            |.:...|:|..:..|..::..||. .::..::|..|  :..|..:.|....|.|:....|.|...
Worm     4 YFESSAISIRRNAAGNDVQKNKVQ-NWLHSVIERLKWWSPGRCQQLFVENELIELCYRAREQFWK 67

  Fly   249 VDITVPDEEKFTICGDIHGQFYDLMNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKL 313
            ..:.:..|....|||||||||.|||.:||:||.| |::.|||.||:||||.||:|.|..||.|::
Worm    68 NKVKLDIEAPVKICGDIHGQFEDLMALFELNGWP-EEHKYLFLGDYVDRGPFSIEVITLLFTFQI 131

  Fly   314 LYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLF 378
            |.|:..||.||||||..:|..|||..|...:|:.|:.|.|...||.:|||..:::||:.||||:
Worm   132 LMPDKVFLLRGNHESRPVNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGI- 195

  Fly   379 STED-VTLDHIRRIERNCQPPEEGLMCELLWSDP-QQWMGLGQSKRGVGIQFGPDVTEKFCKDNN 441
             :|| :.|..:.:|:|....|:.|::.:|.|:|| ::..|...|.||.|..|||:..:||.:.:|
Worm   196 -SEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFGPNAVKKFLQMHN 259

  Fly   442 LDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNNLKPNYKSFEAVPHPDV 506
            ||.::|:|:|...|||...:.:.:||||||:||....|..|.:.: .:.|...:..|    .||:
Worm   260 LDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNV-DDKLLCTFTIF----RPDL 319

  Fly   507 K 507
            |
Worm   320 K 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	121/314 (39%)
		PP2Ac	226..502	CDD:197547	112/277 (40%)
F23B12.1	NP_506574.3	PP2Ac	51..317	CDD:197547	111/273 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810