DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and R08C7.8

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_500563.2	Gene:	R08C7.8 / 177208	WormBaseID:	WBGene00019951	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	346	Identity:	113/346 - (32%)
Similarity:	163/346 - (47%)	Gaps:	66/346 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 DGKVTLKFMKELMEH---YKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICGDIH 266
            :|:..::..|.::||   :........|..|.||.:.::.::..|:::.:    |...||.||||
Worm     3 EGESVVQLAKRMIEHLLKWGVTDAFTDKQIYTILEKAESTLKPLPAMLQV----EHPITIVGDIH 63

  Fly   267 GQFYDLMNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINM 331
            ||...|:..|:..|.| .|..:||.||:||||:.|.|....||.:|:.||:...|.|||||.:.|
Worm    64 GQLDALIRYFDAVGYP-PKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKM 127

  Fly   332 NQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRIERNCQ 396
            |::|||..|:|.|....|...:..|||.||||..:.|:||.||||              |.:||.
Worm   128 NRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGG--------------ISQNCN 178

  Fly   397 PPE---------------EGLMCELLWSDPQQ----WMGLGQSKRGVGIQFGPDVTEKFCKDNNL 442
            ..|               |||..:|:|:||.|    ...:.: :|.:.:.||....:.|.|...|
Worm   179 SWESFKALKKPNTPLTCDEGLQVDLMWADPTQDKCNTFAMNK-QRAISVVFGQKGLDDFLKKLGL 242

  Fly   443 DYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNN------LKP-------- 493
            ..|:|:|||...|:....|.||:||||||.||....|.||.:.::.:.      |:|
Worm   243 SLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPRMIATPEN 307

  Fly   494 ---------NYKSFEAVPHPD 505
                     |||.. .|..||
Worm   308 FEIVKLMENNYKGL-MVASPD 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	113/346 (33%)
		PP2Ac	226..502	CDD:197547	106/317 (33%)
R08C7.8	NP_500563.2	PP2Ac	27..299	CDD:197547	102/291 (35%)
R08C7.8	NP_500563.2	MPP_PPP_family	57..286	CDD:277316	95/244 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900