DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and C23G10.1

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001367544.1	Gene:	C23G10.1 / 175880	WormBaseID:	WBGene00016010	Length:	454	Species:	Caenorhabditis elegans

Alignment Length:	410	Identity:	124/410 - (30%)
Similarity:	202/410 - (49%)	Gaps:	46/410 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 YLKGYYRRAAAHMSLGKFKQALCDFEFVAKCRPNDKD-AKLKFTECNKIVKMRAFERAIAVDKPE 179
            :.||.:::....|.:.|      :.:.:...:|..|| ::|:....|:.:|.......:|:
Worm    55 HFKGDWQKGKQKMLMHK------ELQQIFNGKPGPKDVSRLREMFSNEALKDGPHPLLVAL---- 109

  Fly   180 KTLSEMYSDMENITIEDDYKGPQLEDGKVTLKFMKE-------LMEHY-------KAQKRLHRKF 230
            |.|.:|.:..:|..|:        |.|.....|.|:       ..||:       |...::....
Worm   110 KCLIKMSAVSDNDVIK--------EKGARDKMFQKQSDESNKMFAEHFIKTLLACKGMTKIRTMD 166

  Fly   231 AYKILCEIDTYMRAQPSLVDITVPDEEKFTICGDIHGQFYDLMNIFEINGLPSEKNPYLFNGDFV 295
            .::::.........|.|:|:|..|    ..||||:|||:.||:.:|...|.|.:.| |||.||:|
Worm   167 IFRLIHICKKIFTVQKSMVEIDGP----VRICGDLHGQYPDLIRLFAQGGFPPDSN-YLFLGDYV 226

  Fly   296 DRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEV---TAKYTSAMADIFTQVF 357
            |||||::|.|.....:|..|||:|.:.|||||.|::|:.|||..||   ..:|...:...|.::.
Worm   227 DRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRKGEYHDELYPEFNEMM 291

  Fly   358 NWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQWMGLGQSKR 422
            :.:||...:..:||.||||| |....:||.:|.:.|.....:|.|..:::||||.:..|...:.|
Worm   292 DMMPLVALVGGRILCMHGGL-SQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPAKVSGWTANPR 355

  Fly   423 GVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITIT 487
            |..:|||.:..::.||..::|.|:|.|:|...|||.....|.:||||||:|..:..|..|...::
Worm   356 GASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVS 420

  Fly   488 GNNLKPNYKSFEAVPHPDVK 507
            . .|:   .|||.:...|::
Worm   421 A-GLE---VSFEVLKPEDIR 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	108/327 (33%)
		PP2Ac	226..502	CDD:197547	100/278 (36%)
C23G10.1	NP_001367544.1	PP2Ac	162..432	CDD:197547	100/279 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000