DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kitb and btl

DIOPT Version :9

Sequence 1:	NP_001137390.1	Gene:	kitb / 497629	ZFINID:	ZDB-GENE-050916-2	Length:	957	Species:	Danio rerio
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	1079	Identity:	285/1079 - (26%)
Similarity:	439/1079 - (40%)	Gaps:	242/1079 - (22%)

- Green bases have known domain annotations that are detailed below.

Zfish    43 RCHDDADV-NAGRVRWL-----------RDKGRRIEGELKDDEASVILLNITETQHMGNYTCENT 95
            ||:.|..| |:.|.|.|           |...:....:.....|:::.|...::.:.|||.|.::
  Fly    29 RCYIDVTVENSPRQRHLLSDMDITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNSGNYGCLDS 93

Zfish    96 ETE--EKSSIYIYVKDLG---SAFVR--------------RMVND-------------LQVRKGE 128
            :..  ..|.:..:.:.:|   ::||:              :.:|:             :|...|.
  Fly    94 QNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGG 158

Zfish   129 EITLPCLVTDPAVSHLSLQTC-NGSALPAALTFITHPQGGITIRNVSKAFEGCYFCAGQLDQKPV 192
            ...|.|...||....:::... |.:.:......|...:..:|:..:.....|.|.|...::|...
  Fly   159 LFQLNCSPMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQ 223

Zfish   193 KSREYNLVVRLAPESVPAISLSRNENVILIQDQEFKLSCSAVNINHDFHLRWTIPSEATALESHK 257
            :|....|.|.....:||.:......|..:.......:.|...:...:..:.|.....|..::...
  Fly   224 RSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLL 288

Zfish   258 SNIQPGSR---EYQRSIT-------LWIQSVKINDTGSYRCNARNEKGVSMAAVNLEVY------ 306
            ..::..|:   :..|.||       |.:.:|.:.|.|.|.|.|.|:.|.::||..:::|
  Fly   289 QRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTT 353

Zfish   307 -----------------ERGFINLTEGENRVVEVREG--------------ESL---TLSVEITS 337
                             ..|..|..:.||...|...|              .||   |:::....
  Fly   354 TVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPV 418

Zfish   338 YPKPNDVLWTYNNQELQNTSEHVITLHNQQYR-YISE---LRLVRVHGSEGGIYTFSANHKYESV 398
            |.|.| :.||.:.:.|           |::.. |:.:   ||.|.....:.|:|.....:.:..:
  Fly   419 YGKAN-ITWTKDKKPL-----------NRELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCI 471

Zfish   399 NQSFTVHVICK----PVIV---SQEGPVDGQ--VRCVASGYPVPKISWYYCEPPHTRCSHL---- 450
            ...|:|.:..:    |:||   :|...|:|.  ::|.......|.:||......:.....|
  Fly   472 QFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVE 536

Zfish   451 ---LNATQADEEFAVITVSGSEFGRSE-----VESRLNISKGKFHTLECVASAQGEQAYTLFSIS 507
               ||.|..::. .|:|:....|.:..     ..|.|..|....: |..|:.....:.|.|..
  Fly   537 IQNLNFTVTNDS-VVLTLRNVTFDQEGWYTCLASSGLGRSNSSVY-LRVVSPLPPLEIYALLH-- 597

Zfish   508 ERTVPHKL-FTPLLSGVVST----SVLLSFILVVLLYKYMQKPKYE-IH-W--KVI--------- 554
                .|.| ||.....:|:.    |..::|:|..|..:.:.|.:.| :| |  |||
  Fly   598 ----AHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEG 658

Zfish   555 ---------------------DSFDGNNYTYIDPTQ------LPYDPKWEFPRERLRFGKILGSG 592
                                 .|..|...|  ||.|      .|.|..||.||::|..|.|||.|
  Fly   659 SGCSSGDLQMPVIRIEKQRTTVSTTGTGGT--DPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEG 721

Zfish   593 AFGKVVAATAYGLCSADTV--TTVAVKMLKPSAHSTEKEALMSELKVLSYIGNHINIVNLLGACT 655
            |||:||.|.|.||..:..:  |.|||||:|.....|:..:|:.|::|:..||.||||:||||.|:
  Fly   722 AFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCS 786

Zfish   656 VGGPTLVITEYCCYGDLLNFLRRKRDAFFSSKTGDGYYKNLLSQTQPSIEGTDNGYMPMRSYQKR 720
            .|||..||.||..:|:|.:||::.|..                                 :.|:|
  Fly   787 QGGPLWVIVEYAPHGNLKDFLKQNRPG---------------------------------APQRR 818

Zfish   721 SNQTEWCDDKDDLS---LDTEDLLSFSYQVAKGMDFLTSKNCIHRDLAARNVLLTQGRVAKICDF 782
            |:...:.|||..:|   |..::|..|::|:|:||::|.|:.||||||||||||::.|.|.||.||
  Fly   819 SDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADF 883

Zfish   783 GLARDITRDSNYVLRGNARLPVKWMSPESLFACVYTFESDVWSYGILLWEIFSLGNTPYPGIPVG 847
            ||||||.....|....|.|||:|||:||||....|..:|||||||:|||||.:.|:.|||.|...
  Fly   884 GLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSA 948

Zfish   848 STFYKMIQDGYRMSEPEFAPSEIYEVMRWCWSADPLKRPPFKKLVERTELLLSETTKHD---YLN 909
            ...|..:..|.||.:|......||.|||.||..:...||.|.:|||..:.:|.:.:.:.   ||:
  Fly   949 EELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLD 1013

Zfish   910 LSTSGSCEAFVPPGLQRPQRLSSV--GSSTAS---TQPL 943
            ||.         |.|:.|......  ||.|.:   |.||
  Fly  1014 LSM---------PMLETPPSSGDEDDGSDTETFRETSPL 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kitb	NP_001137390.1	IG_like	121..201	CDD:214653	15/93 (16%)
		Ig	209..305	CDD:299845	20/105 (19%)
		IG	225..305	CDD:214652	18/89 (20%)
		Ig	309..407	CDD:299845	24/118 (20%)
		I-set	319..406	CDD:254352	20/107 (19%)
		PKc_like	547..896	CDD:304357	155/393 (39%)
		Pkinase_Tyr	583..894	CDD:285015	136/315 (43%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653	15/82 (18%)
		IGc2	157..215	CDD:197706	10/57 (18%)
		IG	247..336	CDD:214652	16/88 (18%)
		Ig	258..340	CDD:143165	16/81 (20%)
		I-set	394..479	CDD:254352	18/96 (19%)
		IGc2	408..469	CDD:197706	14/72 (19%)
		IG_like	492..583	CDD:214653	18/92 (20%)
		Ig	507..583	CDD:299845	15/77 (19%)
		PKc_like	700..1000	CDD:304357	143/332 (43%)
		TyrKc	712..996	CDD:197581	137/316 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810