Protein Alignment OPA1 and opa1

DIOPT Version :10

• Sequence 1: XP_047304162.1
• Gene: OPA1 / 4976
• HGNCID: 8140
• Length: 1047
• Species: Homo sapiens
• Sequence 2: XP_009300789.1
• Gene: opa1 / 492332
• ZFINID: ZDB-GENE-041114-7
• Length: 1034
• Species: Danio rerio
• Alignment Length: 1010
• Identity: 777/1010 - (76%)
• Similarity: 873/1010 - (86%)
• Gaps: 24/1010 - (2%)

Human     7 AAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQQFSSLTNLPLR 71
            :.|.|..|:.|:....|:|..:||||||.:||:|:|.:......|||...::.:.::||:.||:|
Zfish     6 SVVTCIACKGLLPSRMGVKFRVPLQKLHPLSRAIHHRYSANNNPQRPPHCSAARHYTSLSRLPMR 70

Human    72 KLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDLSEYKWIV 136
            ..|.....:|||..|.||.||||.|||||||::||||||||||||||:|:||:|:||:|||.|||
Zfish    71 PPKSRSGGHGYQQHRTFWVARLAARLLKLRYILLGSAVGGGYTAKKTYDEWKEMLPDMSEYTWIV 135

Human   137 PDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLKDFFTSGHKLVSEVIGASDLLL 201
            ||.|||:.|.||.:|:..|||..|::.||.||.:||.|:.:.||...:||  |.|||.|||.|.|
Zfish   136 PDFVWELSENIDLDKLASALPELEEIAKLLPDMEKIGENFTFLKSLLSSG--LGSEVNGASGLRL 198

Human   202 LLGSPEETAFRATD-------RGSESDKHFRK-GLLGELILLQQQIQEHEEEARRAAGQY----- 253
            ||.:..|:|.||.|       .....||.|:| |||.|||::|||||:||||.||||...
Zfish   199 LLETTGESALRAPDVPPASAAMADSGDKQFKKQGLLSELIVIQQQIQQHEEEMRRAAANNAPPPP 263

Human   254 ---------STSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKG 309
                     :.|.:|.|||.|||||:||||||||.|||||||:|||||||||||||:||||||||
Zfish   264 RDPSPSPAPNPSPSQSKRKSSDKEKVDQLQEELLRTQLKYQRMLERLEKENKELRKVVLQKDDKG 328

Human   310 IHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSG 374
            ||.||:|||||||||||||:|||||::||||||||||||||||||||||||||||||||||||||
Zfish   329 IHQRKVKKSLIDMYSEVLDILSDYDSNYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSG 393

Human   375 EMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISL 439
            ||||||||||||||||||||:||||||||||.||||||||||||||||||:||||.|||||||||
Zfish   394 EMMTRSPVKVTLSEGPHHVAMFKDSSREFDLGKEEDLAALRHEIELRMRKSVKEGQTVSPETISL 458

Human   440 NVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVT 504
            :|||||:||||||||||||:|||:|||.|||||||||||||||||||||||||||||||||||||
Zfish   459 SVKGPGIQRMVLVDLPGVISTVTTGMAADTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVT 523

Human   505 DLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEA 569
            ||||||||.|:|||||||||||||||:|||||||||:||||||||||||||||||||:.:|||::
Zfish   524 DLVSQMDPQGKRTIFVLTKVDLAEKNLASPSRIQQIVEGKLFPMKALGYFAVVTGKGSPNESIDS 588

Human   570 IREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWK 634
            |::|||:|||||:|||..|||||||||:|||||||||||||||||||||||:|||:|||||||||
Zfish   589 IKDYEEDFFQNSRLLKDGMLKAHQVTTKNLSLAVSDCFWKMVRESVEQQADAFKASRFNLETEWK 653

Human   635 NNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTM 699
            ||||||||||||||:|||||||||||||||||||||||.|||:.|||||||||||||||||||||
Zfish   654 NNYPRLRELDRNELYEKAKNEILDEVISLSQVTPKHWESILQKKLWERVSTHVIENIYLPAAQTM 718

Human   700 NSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESI 764
            ||||||||||||||||||||||:||:|||||||||||:|||.|.|||:.||||||||||||:|||
Zfish   719 NSGTFNTTVDIKLKQWTDKQLPHKALEVAWETLQEEFARFMAEYKGKDQDDIFDKLKEAVKDESI 783

Human   765 KRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKR 829
            ||||||:.|.||||||||||||||||:||.||||||.||||.||:||||||:.|.:|||||||:|
Zfish   784 KRHKWNERAMDSLRVIQHNALEDRSITDKPQWDAAIQFMEETLQSRLKDTESVIADMVGPDWKQR 848

Human   830 WLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 894
            |:.|||||.||...||||||||::||.:|:|.||||:||:||||||||:|||||||.||||||||
Zfish   849 WMSWKNRTPEQHTRNETKNELERLLKLHEDHTAYLANDEVTTVRKNLEARGVEVDPVLIKDTWHQ 913

Human   895 VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVR 959
            ::|||||:.||.||||||||||||||||||||||||||||||||||||.||||||||||||||||
Zfish   914 LFRRHFLQKALLHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLGITANTLRQQLTNTEVR 978

Human   960 RLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDL 994
            |||||||||||||.||.|||::|:||:||||||||
Zfish   979 RLEKNVKEVLEDFGEDNEKKVQLITGRRVQLAEDL 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPA1	XP_047304162.1	DLP_1	342..616	CDD:206738	248/273 (91%)
		OPA1_C	672..994	CDD:466080	269/321 (84%)
opa1	XP_009300789.1	DLP_1	361..635	CDD:206738	248/273 (91%)
		OPA1_C	691..1034	CDD:466080	271/323 (84%)