Protein Alignment OPA1 and shi

DIOPT Version :10

• Sequence 1: XP_047304162.1
• Gene: OPA1 / 4976
• HGNCID: 8140
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_001259588.1
• Gene: shi / 45928
• FlyBaseID: FBgn0003392
• Length: 896
• Species: Drosophila melanogaster
• Alignment Length: 795
• Identity: 172/795 - (21%)
• Similarity: 310/795 - (38%)
• Gaps: 189/795 - (23%)

Human   318 SLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPV 382
            |||.:.:::.|..:  ....:.|..||::.|||.|||||:||||........||||| ::||.|:
  Fly     3 SLITIVNKLQDAFT--SLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSG-IVTRRPL 64

Human   383 KVTLSEGPH------HVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNV 441
            .:.|..|..      |:...|.||  ||        .:|.|||....:.......:|...|:|.|
  Fly    65 ILQLINGVTEYGEFLHIKGKKFSS--FD--------EIRKEIEDETDRVTGSNKGISNIPINLRV 119

Human   442 KGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDL 506
            ..|.:..:.|:||||:..........|.::.|..:...:::....:||.:...:.|...|....|
  Fly   120 YSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKL 184

Human   507 VSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIR 571
            ..::||.|.|||.|:||:||.::...:    :.|:|.||.|::. ||..||   ..|.:.||..:
  Fly   185 AKEVDPQGVRTIGVITKLDLMDEGTDA----RDILENKLLPLRR-GYIGVV---NRSQKDIEGRK 241

Human   572 EY------EEEFFQN-------SKLLKTSMLKAHQVTTRNLSLAVSDCF----WKMVRE--SVEQ 617
            :.      |.:||.:       :..|.|..|:  :|..:.|:..:.|..    .|:.::  ::|:
  Fly   242 DIHQALAAERKFFLSHPSYRHMADRLGTPYLQ--RVLNQQLTNHIRDTLPGLRDKLQKQMLTLEK 304

Human   618 QADSFK---------ATRFNLE--TEWKNNYPRLRE------LDRNELFEKAK-NEILDEVISLS 664
            :.:.||         .|:..|:  .:.::::.|..|      ::.|||...|| |.|..|.:...
  Fly   305 EVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFE 369

Human   665 QVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAW 729
            .|.....|:.|::.:     :..|.||:                .|::..:|.        ::|:
  Fly   370 IVKMACDEKELRREI-----SFAIRNIH----------------GIRVGLFTP--------DMAF 405

Human   730 ETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQ 794
            |.:.:.....:.||..|..|.:..:|...|:..:.|..::....|::.|:|..: :..|..|.|:
  Fly   406 EAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERIITTH-VRQREHSCKE 469

Human   795 QWDAAIYFMEEALQARLKD----------TENA-------------------IENM--------- 821
            |....|.|....:....:|          :|||                   |:|:
  Fly   470 QILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLG 534

Human   822 ---------VGPDWKKRWLYWKNRTQEQCVHNETKNELEKM-------LKCNEEHPAYLA-SDEI 869
                     ..|.......||...|.|.....:.::|.||.       ||..:....::: |..:
  Fly   535 RSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRV 599

Human   870 TTVRKNLESRGV-------EVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVD--- 924
            |....:.:.|.|       |:....::|.  :.::..||          |.|.|..::...:
  Fly   600 TFALFSPDGRNVYKDYKQLELSCETVEDV--ESWKASFL----------RAGVYPEKQETQENGD 652

Human   925 ---SELECNDVVLFWRIQRM-------LAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKK 979
               ||...:|..|..:::.:       :.|...|.|..:....:..:..|.|:.:     :||..
  Fly   653 ESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFI-----NGELL 712

Human   980 IKL-LTGKRVQLAED 993
            ..| .:|.:.|:.|:
  Fly   713 AHLYASGDQAQMMEE 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPA1	XP_047304162.1	DLP_1	342..616	CDD:206738	84/298 (28%)
		OPA1_C	672..994	CDD:466080	67/398 (17%)
shi	NP_001259588.1	DYNc	1..240	CDD:197491	79/257 (31%)
		Dynamin_M	210..498	CDD:460033	64/327 (20%)
		PH_dynamin	512..644	CDD:269958	23/143 (16%)
		GED	664..755	CDD:128597	12/69 (17%)
		FAP	725..>855	CDD:429334	1/3 (33%)