Protein Alignment OPA1 and fzo

DIOPT Version :10

• Sequence 1: XP_047304162.1
• Gene: OPA1 / 4976
• HGNCID: 8140
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_732840.1
• Gene: fzo / 42745
• FlyBaseID: FBgn0011596
• Length: 718
• Species: Drosophila melanogaster
• Alignment Length: 852
• Identity: 158/852 - (18%)
• Similarity: 285/852 - (33%)
• Gaps: 263/852 - (30%)

Human   254 STSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKS 318
            |:|.::....|..|.::..:..:|.:....:..|||          :.||.||.:.:.|.....|
  Fly    19 SSSSSRLSEFVDAKTELQDIYHDLSNYLSNFLTILE----------ETVLLKDRQMLEHLCAFSS 73

Human   319 LIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRS--- 380
            .::..::||           ::|.: :|...|..|.||::|:..:...:|.|...|.  |.|
  Fly    74 RVEAIAKVL-----------SRDRM-KVAFFGRTSNGKSAVINALLHEKILPSAMGH--TTSCFC 124

Human   381 PVKVTLSEGPHHVALFKDSSREFDLTKEEDLA------ALRHE--IELRMRKNVKEGCTVSPETI 437
            .|:...|....||.: :......:|:....||      ||:..  :::.|.||   .|::....:
  Fly   125 QVQANGSNETEHVKV-EQEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKN---RCSILDYDV 185

Human   438 SLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV--DAER 500
                        ||:|.|||          |....:.....:|..:.:..||.:...|.  ..||
  Fly   186 ------------VLMDTPGV----------DVTAQLDDCLDSYCMDADVFILVLNAESTVSRVER 228

Human   501 SIVTDLVSQMDPHGRRTIFVLTK------------------------VDLAEKNVASPSRIQQII 541
            ....|:.|::   .|..:|:|..                        |:|....:...|..|:..
  Fly   229 QFFKDVASKL---SRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYSTAQEAW 290

Human   542 EGKLFPMKALGYFAVVTGK-----GNSSESIEAIREYEEEFFQNSKLLKTSMLKA----HQVTTR 597
            | :::.:.||....:..|:     |.:.:..:....:|.:|   |..|..|.||.    |.::.:
  Fly   291 E-RIYHVSALEALHIRNGQITNPSGQTQQRYQEFLRFENDF---SNCLAVSALKTKFGPHLLSAQ 351

Human   598 NLSLAVSDCFWKMVRESVEQQADSFKATRFNLETE---W-----------KNNYPRLREL----D 644
            .:...:.........|.|.:..|..|..|.||..|   |           :..:..|.|:    .
  Fly   352 KILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQRVG 416

Human   645 RNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWER---------VSTHVIENIYLPAAQTMN 700
            |..|.::.|..|...|:|.||  |.|.|...|...::|         :...|::.:.:|..:.:
  Fly   417 RCVLNDQIKTLIPSSVLSFSQ--PFHPEFPAQIGQYQRSLCAHLDKLLEDRVLQCLSIPLQRKI- 478

Human   701 SGTFNTTVDIKLKQWTDKQ--LPNKAVEVAWETL-----QEEFSRFMTEPKGK------------ 746
                   :||      :|:  ||.......|:.:     |...|.|..:.:.:
  Fly   479 -------LDI------EKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRL 530

Human   747 -----EHDDIF--DKLKEAVKEES-----IKRHKWNDF-----AEDSLRVIQHNALEDRSISDKQ 794
                 .|...|  .||:...|:.|     :..:.|...     ::.||..:..:|:..||.:
  Fly   531 EGNLPLHASPFRIQKLQNGHKKCSPLPPLVNGNHWQMLESLVKSKGSLGTVLLSAMAIRSFN--- 592

Human   795 QWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEE 859
             |...:                .:..:||..:...:..|....||:...::....|::.|:
  Fly   593 -WPIVL----------------ILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLR---- 636

Human   860 HPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVD 924
                  ||...||      .|.|:.           .|:| |.|..|    |
  Fly   637 ------SDVQQTV------SGFELQ-----------LRQH-LATVRN----C------------- 660

Human   925 SELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQ 989
            .|.:.|:.:      ..|.:....|.:|:.:.||.:|.      |:.|.:.|:    ||..:...
  Fly   661 WEAQSNETL------NDLNVRTAELTKQIQSMEVLQLS------LKKFRDKGQ----LLASRLGD 709

Human   990 LAEDLIT 996
            ..|..:|
  Fly   710 FQETYLT 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPA1	XP_047304162.1	DLP_1	342..616	CDD:206738	60/319 (19%)
		OPA1_C	672..994	CDD:466080	60/366 (16%)
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	54/282 (19%)
		Fzo_mitofusin	566..716	CDD:461432	39/230 (17%)