Protein Alignment OPA1 and Opa1

DIOPT Version :10

• Sequence 1: XP_047304162.1
• Gene: OPA1 / 4976
• HGNCID: 8140
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Alignment Length: 946
• Identity: 490/946 - (51%)
• Similarity: 650/946 - (68%)
• Gaps: 69/946 - (7%)

Human    65 LTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDL 129
            |...|.|..:..|...||    .....|:....|||||::||.|:|||.:..|.:::|||.:|:
  Fly    61 LAGNPARGWQMPPPSRGY----GMLVVRILRGALKLRYIVLGGAIGGGVSLSKKYEEWKDGLPN- 120

Human   130 SEYKWIVPDIVWEIDEYIDFEK--------IRKALPSSEDLVKLAPDFDKIVESLSLLKDFFTSG 186
              :||: .|.:.:.:.:..|.:        ::.|:.....|.:|..|      .||..:::|.|
  Fly   121 --FKWL-EDAMPQGERWSQFSRNLIEVGSLVKNAIEVDPKLKQLGED------KLSEWRNWFDS- 175

Human   187 HKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQEHEEEAR---R 248
              .:.:.|.|:|.                          :|:         ||.|.:::.:   .
  Fly   176 --RLDDAIEAADY--------------------------QGV---------QIVETKDDLKAKTT 203

Human   249 AAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK--LVLQKDDKGIH 311
            .|....||...:|:....:.:::.||.|:::.|:|||:.||::||||:|||:  |:| |.:|...
  Fly   204 VAALGITSDESRKKYEKLQSQVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLIL-KTNKKTT 267

Human   312 HRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
            .:|:|||||||||||||.||.||..|...|||||||||||||:|||||||.||:|||||||||||
  Fly   268 AKKIKKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEM 332

Human   377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNV 441
            |||:||||||:|||:|||.|:||.||:|||||.||..||.::|.||:.:|:.|.|||.|.|::.|
  Fly   333 MTRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTV 397

Human   442 KGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDL 506
            |||||||||||||||:|:|:|..||.|||::|..::|.||.|||||||||||||||||||.||||
  Fly   398 KGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDL 462

Human   507 VSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIR 571
            |.|.||.|||||||||||||||: :|.|.||::|:.|||||||||||:|||||:|...:||:|||
  Fly   463 VMQCDPLGRRTIFVLTKVDLAEE-LADPDRIRKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIR 526

Human   572 EYEEEFFQNSKLL-KTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKN 635
            :|||:||:||||. :..::..||||:|||||||||.|||||||::|||||:||||||||||||||
  Fly   527 QYEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKN 591

Human   636 NYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMN 700
            |:|||||..|:|||:|||.||||||::|||::.|.|::.|...|||::|.:|.|:|||||||:.:
  Fly   592 NFPRLRESGRDELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGS 656

Human   701 SGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFM-TEPKGKEHDDIFDKLKEAVKEESI 764
            ..:|||.|||||:||.::.||.|:||..||.||:||...| ...|.::||.|||:||.||.:|:|
  Fly   657 QNSFNTMVDIKLRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAI 721

Human   765 KRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKR 829
            :||.|.|.|.|.|||||.|.||||.:.|||:||:|:.|:|.::.|:|..||..:..|.||...:|
  Fly   722 RRHSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRR 786

Human   830 WLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 894
            ..:|:..||:|......||||:|:||.:.:|...|..||:|||||||:...|:||...|:.||..
  Fly   787 ITHWQYLTQDQQKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFP 851

Human   895 VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVR 959
            |||:|||:.||.....||:.:|.|.:...:.|:.|:|||||||||:::.||.|.||||:.|.|.|
  Fly   852 VYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREAR 916

Human   960 RLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLI 995
            ||:|.:|.||::|::|.|||..|||||||.|||:||
  Fly   917 RLDKEIKAVLDEFSDDEEKKGYLLTGKRVLLAEELI 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPA1	XP_047304162.1	DLP_1	342..616	CDD:206738	197/274 (72%)
		OPA1_C	672..994	CDD:466080	162/322 (50%)
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	197/274 (72%)
		OPA1_C	629..972	CDD:466080	164/324 (51%)