Protein Alignment OPA1 and Drp1

DIOPT Version :10

• Sequence 1: XP_047304162.1
• Gene: OPA1 / 4976
• HGNCID: 8140
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Alignment Length: 653
• Identity: 141/653 - (21%)
• Similarity: 248/653 - (37%)
• Gaps: 182/653 - (27%)

Human   317 KSLIDMYSEVLDVLSDYDASYNT----QDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMM 377
            ::||.:.:::.||       :||    ...||::||:|.||:||:||:|.:......|||:| ::
  Fly     2 EALIPVINKLQDV-------FNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTG-IV 58

Human   378 TRSPVKVTLSEGP-----HHVALFKDSSRE----FDLTKE--EDLAALRHEIELRMRKNVKEGCT 431
            ||.|:.:.|...|     :..|....|:.|    |..||:  .|...:|.|||....:.......
  Fly    59 TRRPLVLQLIYSPLDDRENRSAENGTSNAEEWGRFLHTKKCFTDFDEIRKEIENETERAAGSNKG 123

Human   432 VSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496
            :.||.|:|.:....:..:.||||||:..........|.:..|..:...|::|||:|||.:...:.
  Fly   124 ICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANT 188

Human   497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKG 561
            |...|....|...:||.||||:.|:||:||.:   |....| .|:.|::.|:| ||...|:   .
  Fly   189 DMATSEALKLAKDVDPDGRRTLAVVTKLDLMD---AGTDAI-DILCGRVIPVK-LGIIGVM---N 245

Human   562 NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRN------------LSLAVSDC-------- 606
            .|.:.|...:..:::....:..|:.   |...:.|||            |...:.||
  Fly   246 RSQKDIMDQKHIDDQMKDEAAFLQR---KYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRV 307

Human   607 ------FWKMVRESVEQQADSFKATRFNLETEWKNNY-----PRLRELDRNEL---------FEK 651
                  |..::....|..:|. ..|...:.|::.:.|     ...|.::..||         |.:
  Fly   308 NIMATQFQSLLNSYGEDVSDK-SQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHE 371

Human   652 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWT 716
            .....||.:..|:.::.......::.:...|.:      :::|
  Fly   372 TFGRTLDSIHPLAGLSKMDILTAIRNATGPRPA------LFVP---------------------- 408

Human   717 DKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQ 781
                     ||::|.|.:...|.:.||..:..:.|.::::..|      :|..|:..::.||..:
  Fly   409 ---------EVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIV------QHCGNEVQQEMLRFPK 458

Human   782 -HNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNE 845
             |..:.|              .:.:.|:.||..|...:||:|..:
  Fly   459 LHEKIVD--------------VVTQLLRRRLPHTNVMVENIVAIE-------------------- 489

Human   846 TKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIK---DTWHQV---YRRHFLKTA 904
                   :...|.:||.:              .:...:.|||:|   |.:.|:   .||  ..|.
  Fly   490 -------LAYINTKHPDF--------------HKDAALVPSLLKTDSDPYSQINLGQRR--ANTP 531

Human   905 LNH 907
            .||
  Fly   532 RNH 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPA1	XP_047304162.1	DLP_1	342..616	CDD:206738	85/310 (27%)
		OPA1_C	672..994	CDD:466080	38/243 (16%)
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	84/289 (29%)
		Dynamin_M	224..507	CDD:460033	58/389 (15%)
		GED	639..729	CDD:460495