Protein Alignment OPA1 and dnm1

DIOPT Version :10

• Sequence 1: XP_047304162.1
• Gene: OPA1 / 4976
• HGNCID: 8140
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_596014.1
• Gene: dnm1 / 2540159
• PomBaseID: SPBC12C2.08
• Length: 781
• Species: Schizosaccharomyces pombe
• Alignment Length: 816
• Identity: 177/816 - (21%)
• Similarity: 318/816 - (38%)
• Gaps: 192/816 - (23%)

Human   317 KSLIDMYSEVLDVLSDYDASYNT--QD--HLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMM 377
            :.||.:.:::.|::      |||  .|  .||.:||||.||.||:||||.|......|||:| ::
pombe     2 EQLIPLVNQLQDLV------YNTIGSDFLDLPSIVVVGSQSCGKSSVLENIVGKDFLPRGTG-IV 59

Human   378 TRSPVKVTL------SEGPHHVALFKDSSRE-----------------------------FDLTK 407
            ||.|:.:.|      ::..|......|::.|                             ...||
pombe    60 TRRPLILQLINLKRKTKNNHDEESTSDNNSEETSAAGETGSLEGIEEDSDEIEDYAEFLHIPDTK 124

Human   408 EEDLAALRHEIE---LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDT 469
            ..|:..:|.|||   ||: ....:|....|  |:|.:....:..:.|:||||:..........|.
pombe   125 FTDMNKVRAEIENETLRV-AGANKGINKLP--INLKIYSTRVLNLTLIDLPGLTKIPVGDQPTDI 186

Human   470 KETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASP 534
            :....|:...|:..||:|||.:...:.|...|....|...:||.|:|||.||||:||.::.
pombe   187 EAQTRSLIMEYISRPNSIILAVSPANFDIVNSEGLKLARSVDPKGKRTIGVLTKLDLMDQG---- 247

Human   535 SRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIR---EYEEEFFQNSKLLKTSMLKAHQVTT 596
            :....|:.|:::|:| ||:.|.|....:...|.:::|   :.|..||::....:|  :| .:..|
pombe   248 TNAMDILSGRVYPLK-LGFVATVNRSQSDIVSHKSMRDALQSERSFFEHHPAYRT--IK-DRCGT 308

Human   597 RNLSLAVSDCFWKMVRESVEQQADSFKA---TRFNLETEWKNNYPRLRELDRNE---LFEKAKNE 655
            ..|:..:|:.....:||    :....||   |..:...:..|||...:..|:::   :..:|.|.
pombe   309 PYLAKTLSNLLVSHIRE----RLPDIKARLSTLISQTQQQLNNYGDFKLSDQSQRGIILLQAMNR 369

Human   656 ILDEVI-----SLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIK--LK 713
            ..:..|     :.|.:..|      :.|...|:.: :..|::..|..:::.....:||||:  :.
pombe   370 FANTFIASIDGNSSNIPTK------ELSGGARLYS-IFNNVFTTALNSIDPLQNLSTVDIRTAIL 427

Human   714 QWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLR 778
            ..|..:......|:|::.|.:.....:..|.   |..:     |.|.||.:|
pombe   428 NSTGSRATLFLSEMAFDILVKPQLNLLAAPC---HQCV-----ELVYEELMK------------- 471

Human   779 VIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVG----------PDWKKRWLYW 833
            :..::...|.|...|.| .|.:..:.:.|:..|..|.:.:|:::.          ||:     ..
pombe   472 ICHYSGDSDISHFPKLQ-TALVETVSDLLRENLTPTYSFVESLIAIQSAYINTNHPDF-----LG 530

Human   834 KNRTQEQCVHNETKNELEKMLKCNEEHPAYLASD---------------------------EITT 871
            ........:..:.:|.|  ||....:.|...|.|                           ||||
pombe   531 VQGAMAVVLSRKEQNRL--MLSQENDEPISSALDTVKPDGIELYSSDPDTSVKSITNKATNEITT 593

Human   872 VRKNLESRGVEVDPSLIKDTWHQVY------RRHFLKTALNHCNLCRRGFYYYQRHFVD--SELE 928
            ::.:..::...:| .|....::..:      |:.||.......|..|:..      .:|  |...
pombe   594 LKSDDSAKMQPLD-VLASKRYNNAFSTETAERKTFLSYVFGANNATRKAM------SIDKSSSYP 651

Human   929 CNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEV-LEDFAEDGEKKIKLLTGKRVQLAE 992
            .||.:          ...:|..:.....::..|...|:.: |||.:|..|.::.|:        :
pombe   652 LNDSL----------SGGDTNHKNNHPLKMTDLSNEVETMALEDMSEREEVEVDLI--------K 698

Human   993 DLITDIFPSNL---LLVVMLRDISWDCMVVAHRDTI 1025
            :|||..|  ||   :::..:..:....:|.|.:|.|
pombe   699 ELITSYF--NLTRKIIIDQVPKVIMHLLVNASKDAI 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPA1	XP_047304162.1	DLP_1	342..616	CDD:206738	87/314 (28%)
		OPA1_C	672..994	CDD:466080	61/369 (17%)
dnm1	NP_596014.1	DLP_1	24..328	CDD:206738	87/319 (27%)
		Dynamin_M	249..536	CDD:460033	62/328 (19%)
		GED	690..780	CDD:460495	12/53 (23%)