Protein Alignment OPA1 and eat-3

DIOPT Version :10

• Sequence 1: XP_047304162.1
• Gene: OPA1 / 4976
• HGNCID: 8140
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_495986.3
• Gene: eat-3 / 174476
• WormBaseID: WBGene00001134
• Length: 964
• Species: Caenorhabditis elegans
• Alignment Length: 912
• Identity: 464/912 - (50%)
• Similarity: 631/912 - (69%)
• Gaps: 52/912 - (5%)

Human    91 ARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKA 155
            |..|..||||||.|....:||...|:..:::||..:||||..:|...:..|.     :|.:..|.
 Worm    75 ASAARHLLKLRYFIATGVIGGSVAARTWYEEWKSNLPDLSLPEWFDSNGSWN-----EFSQKMKG 134

Human   156 LPSSEDLVKLAPDFDKIVESLSLLKDFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSES 220
            :.....    |...:|..|.::..:.|     |...|              ::........|.|.
 Worm   135 IKDGFG----ADGQNKWAEWMAKFEQF-----KQQKE--------------DQNGNSGGGGGGEG 176

Human   221 DKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQ 285
            :...::.::  |..|.......::|..           ::|..||.:|:|.:||||:|.||.:||
 Worm   177 NVPVKEPVI--LASLMSAFSSKKDEPE-----------EKKDNVSAEERIQKLQEEMLKTQSQYQ 228

Human   286 RILERLEKENKELRKLVLQKDDK-GIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVV 349
            |.|||||||||.|::.:|..||| .|..::||:|||||||||||:|::||:||||.|:|||||||
 Worm   229 RELERLEKENKVLKQRLLLSDDKAAIRLKRLKRSLIDMYSEVLDLLNEYDSSYNTSDNLPRVVVV 293

Human   350 GDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAAL 414
            |||||||||||||:||||||||||||||||:||||||||||:|||.|:|||||||||||.||..|
 Worm   294 GDQSAGKTSVLEMVAQARIFPRGSGEMMTRAPVKVTLSEGPYHVAQFRDSSREFDLTKETDLQQL 358

Human   415 RHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 479
            |:|.|:|||.:|::|.|||.|.|||.||||.|.|||||||||||:|||:.||.:||:.|..:|||
 Worm   359 RNETEVRMRNSVRDGKTVSNEVISLTVKGPNLPRMVLVDLPGVISTVTADMARETKDDIIRMSKA 423

Human   480 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGK 544
            :|:|||||||||||||||||||.||||||.:||.|:|||.||||||:||||:|:|.||::|:|||
 Worm   424 HMENPNAIILCIQDGSVDAERSNVTDLVSSIDPSGKRTILVLTKVDMAEKNLANPDRIKKILEGK 488

Human   545 LFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWK 609
            ||||||||||.||||:||||:||:.||:|||.||..|:||:..:||..|:||||:|||||||||:
 Worm   489 LFPMKALGYFGVVTGRGNSSDSIDEIRKYEENFFSTSQLLRDGVLKPSQMTTRNMSLAVSDCFWR 553

Human   610 MVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEI 674
            |||:|:|.|.|:|:|.:||||.||||::.|:|:|:|:||::||:.|||||:::||.:..:.||::
 Worm   554 MVRDSIESQTDAFRAAKFNLEAEWKNHFLRIRQLNRDELYDKARGEILDEIVNLSLIGVEEWEKL 618

Human   675 LQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRF 739
            ||..||..:|:||.:.|.:||..:.:||:||||||||||.:.||||..|::|..|:||:|.|.|.
 Worm   619 LQDKLWSGISSHVFDQILMPAYASSSSGSFNTTVDIKLKHFADKQLAQKSIETGWDTLKEVFFRQ 683

Human   740 MTEP--KGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYF 802
            :.:.  ..|:||.:||.|||||.||::..|.|:|.|.|.|||||.||:|||::.||:.||||..|
 Worm   684 INQDARTKKDHDPVFDALKEAVIEEAMLTHGWDDKAMDYLRVIQLNAMEDRAVQDKRSWDAACNF 748

Human   803 MEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQE---QCVHNETKNELEKMLKCNEEHPAYL 864
            :.:|...||...:..:.:..||.|..:||.||..|.:   .||   .::||..:|..:.||...|
 Worm   749 LHKAASERLAAVKKQLTDDRGPGWASKWLMWKTPTADNHYSCV---IQDELYSILGADPEHKQAL 810

Human   865 ASDEITTVRKNLESRGV-EVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVD-SEL 927
            ..|:||.:|:|:|::|| ||....|:..|..|:::|||:..:|....|...:..|::..:: .::
 Worm   811 TDDDITVIRRNIETKGVLEVPTESIRKQWKLVFKKHFLERIINSSKDCLSMYQMYRQGMIEGQDI 875

Human   928 ECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAE 992
            :|..:|||:|||:|:.:|.|.||||:||||.|||||.:||||:|::::.:.|.|.|||:||.|||
 Worm   876 DCQTIVLFYRIQKMVNLTCNALRQQITNTEHRRLEKEIKEVLDDWSQEPDIKKKYLTGRRVDLAE 940

Human   993 DL 994
            ::
 Worm   941 EI 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPA1	XP_047304162.1	DLP_1	342..616	CDD:206738	206/273 (75%)
		OPA1_C	672..994	CDD:466080	145/328 (44%)
eat-3	NP_495986.3	CwlO1	195..>311	CDD:443091	74/126 (59%)
		DLP_1	286..560	CDD:206738	206/273 (75%)
		OPA1_C	616..963	CDD:466080	145/330 (44%)