DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Catr and CTNNAL1

DIOPT Version :9

Sequence 1:	NP_726389.4	Gene:	alpha-Catr / 49713	FlyBaseID:	FBgn0029105	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_003789.1	Gene:	CTNNAL1 / 8727	HGNCID:	2512	Length:	734	Species:	Homo sapiens

Alignment Length:	789	Identity:	224/789 - (28%)
Similarity:	388/789 - (49%)	Gaps:	121/789 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 STVNNQRFRVRDMDNEQIMSTFGNIGHLLNIAVERFITIGEIIAEENIDIKGDMYEAAKEARDAG 71
            :|:.|.:...:..|  :.:.....:|..:|:||.||:.:||.||.||.|:|.::..|..||:.||
Human    49 TTLINHKDNTKKSD--KTLQAIQRVGQAVNLAVGRFVKVGEAIANENWDLKEEINIACIEAKQAG 111

  Fly    72 KSIERLCDISPLSGMELRHHIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASE 136
            ::|..|.||:.|:.:|....|....|...:|.|||.||||||::|||.|.:|:|:::|::.:...
Human   112 ETIAALTDITNLNHLESDGQITIFTDKTGVIKAARLLLSSVTKVLLLADRVVIKQIITSRNKVLA 176

  Fly   137 SLEKLESVMNFTEFVRAFSVFGTEMIELAYLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTS 201
            ::|:||.|.:|.|||:.||.||.||:|.|:|:|..:|..|:|:::|:|.:||.:|||...:|||:
Human   177 TMERLEKVNSFQEFVQIFSQFGNEMVEFAHLSGDRQNDLKDEKKKAKMAAARAVLEKCTMMLLTA 241

  Fly   202 SKNSLIHSDCVIVKENRDTVFCQIRRAMDLIHFVVKDSIFDTAKHMPFEKQASNPNYENE----S 262
            ||..|.|.:|....:|::.||.:::.|:|.:..:|.|               ..||.|.:    |
Human   242 SKTCLRHPNCESAHKNKEGVFDRMKVALDKVIEIVTD---------------CKPNGETDISSIS 291

  Fly   263 IYTTIKRIVNLIKRYKYQMSYYEGSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGGGRMVNNTNF 327
            |:|.||         :::|           |.:|                              .
Human   292 IFTGIK---------EFKM-----------NIEA------------------------------L 306

  Fly   328 RKHLSSESLDLREELSLAFEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLYLNTIMKDQ 392
            |::|..:|   :|.||:..|.:.|:..|||||.|.||.||:.||......::|....::..::.|
Human   307 RENLYFQS---KENLSVTLEVILERMEDFTDSAYTSHEHRERILELSTQARMELQQLISVWIQAQ 368

  Fly   393 HEGGGGAGGVGGVGGGQVKGRS---DPELGMLS---SLEELCKQLVVSVSSQIEDFNESLKICSK 451
            .:                |.:|   :.||.:|.   ||.||.|:|..:.:....|.   ||..:.
Human   369 SK----------------KTKSIAEELELSILKISHSLNELKKELHSTATQLAADL---LKYHAD 414

  Fly   452 --LVKSFHVLATNYDIDNLNQRSSKFHDCCDHIFDICKLLQHIAPTERLQVQAKCLAINLRIYGP 514
              ::|:..:.....:::.|.:.:.|..:..:.:.:.|:||:||:.||.|::.........::.|.
Human   415 HVVLKALKLTGVEGNLEALAEYACKLSEQKEQLVETCRLLRHISGTEPLEITCIHAEETFQVTGQ 479

  Fly   515 QVFIAAKILWKYSNSSAANENFESFSDMWKWLTNEISMIAKKILVSINTTKGDR----DADAEKC 575
            |:..||:.|..:.:|..|.||.:.|.:.|:...:::|.:.::|.......:|::    .......
Human   480 QIISAAETLTLHPSSKIAKENLDVFCEAWESQISDMSTLLREINDVFEGRRGEKYGYLSLPKPMK 544

  Fly   576 ESSSDKLTKSGVPATEDGEMVEYSGLE-GKNNGDLNTYQSKWSEDLSDDNDILKRAKNMSAMAFL 639
            .:::.|..|...|.:|:...:...||: |....|.:....||.:   .:|:|::..:|||:||:.
Human   545 NNANLKSLKPDKPDSEEQAKIAKLGLKLGLLTSDADCEIEKWED---QENEIVQYGRNMSSMAYS 606

  Fly   640 MYQFTKGNGSLRTTQDLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQAL 704
            :|.||:|.|.|:|:|||..|.|.||.|..:|...::.||.|:...|....||.|...:|...| |
Human   607 LYLFTRGEGPLKTSQDLIHQLEVFAAEGLKLTSSVQAFSKQLKDDDKLMLLLEINKLIPLCHQ-L 670

  Fly   705 QFTVKDHTVGKAATFVKVDHVIRETKNLMNVINKVVSKCFECATKYKLNLTGITGGLTSERSNEN 769
            |...|.....|  .|:|||..|.:|:::|.::.:::|.|::...|.::.    ..|..|..:.:.
Human   671 QTVTKTSLQNK--VFLKVDKCITKTRSMMALLVQLLSLCYKLLKKLQME----NNGWVSVTNKDT 729

  Fly   770 MAGGMCDSK 778
            |     |||
Human   730 M-----DSK 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	52..755	CDD:279395	205/719 (29%)
CTNNAL1	NP_003789.1	Vinculin	92..675	CDD:279395	193/673 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3927
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2815
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2818
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46067
OrthoDB	1	1.010	-	-		D127258at33208
OrthoFinder	1	1.000	-	-		FOG0007235
OrthoInspector	1	1.000	-	-		oto88453
orthoMCL	1	0.900	-	-		OOG6_107795
Panther	1	1.100	-	-	LDO	PTHR46342
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5795
SonicParanoid	1	1.000	-	-		X5337
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870