Protein Alignment alpha-Catr and vcla

DIOPT Version :10

• Sequence 1: NP_726389.4
• Gene: alpha-Catr / 49713
• FlyBaseID: FBgn0029105
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: NP_001122153.1
• Gene: vcla / 552980
• ZFINID: ZDB-GENE-050506-61
• Length: 1131
• Species: Danio rerio
• Alignment Length: 1121
• Identity: 188/1121 - (16%)
• Similarity: 337/1121 - (30%)
• Gaps: 450/1121 - (40%)

  Fly    38 AVERFITIGEIIAEENID--IKGDMYEAAKEARDA-GKSIE--RLCDISPLSGMELRHHIEPLKD 97
            ||...:.:|:...:...|  :|.||..|..:..:| .|.:|  ::....|.|        .|.:|
Zfish    50 AVSNLVRVGKETVQTTEDKIMKRDMPSAFIKVENACAKLVEAAQMLRTDPYS--------VPARD 106

  Fly    98 YGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESLEKLESVMNFTEFVRAFSVFGTEMI 162
            |  :|..:|.:||..:.:||..|...|:|::...|...|.|...|.|....:.:......|..|.
Zfish   107 Y--LIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLITYTKNLGPGMT 169

  Fly   163 ELAYLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTSSKNSLIHSDCVI---VKE---NRDTV 221
            ::|.:....:.....:..|..:.::...:::.:.:|:::.| ..:.:.|..   |:|   ||:..
Zfish   170 KMAKMIDERQQELTHQEHRVMLVTSMNTVKELLPVLISAIK-IFVTTKCTKSHGVEEALKNRNYT 233

  Fly   222 FCQ------------------------------IRRAMDLIHFVV-------------------- 236
            |.:                              ::||:.||...:
Zfish   234 FDKMTAEINEIIRVLQLTSWDEDAWANKKDTEAMKRALALIESKMGQAKGWLRDPNALPGDPGEH 298

  Fly   237 --------------------KDSIFDTAKHM------------------PFEKQASNP------- 256
                                :..|..|||.:                  |...|.:..
Zfish   299 ALRQILDEAGKVGELCAGKERREILGTAKTLGQMTDQVSDVRARGQGATPMGMQKAQQVAQGLDI 363

  Fly   257 ---NYEN-----ESIYTTIKRIVNLIKRYKYQMSYYEGSGEGNNNSDAYFS----FLD------- 302
               ..||     |::....:.|...|...:..::...|..||..|..|..:    ..|
Zfish   364 LVGKVENAARKLEALTNAKQAIAKRIDNAQSWLADPNGGPEGEENIRALLAEAKRIADLCEDPKE 428

  Fly   303 -DDLWKSEKNLPSAAG-GGRMVNNTNFRKHLSSESLDLREELSLAFEKLFEKAHDFTDSPYISHN 365
             ||:.:|   :...|| ..|:|......|..:.|:..|.:::..|.:.|..|.:...      .|
Zfish   429 RDDILRS---IGEIAGLTARLVELRRIGKGDTPEARALAKQIGTALQNLQAKTNRAV------AN 484

  Fly   366 HRKNILSYCDNCKLEFDL-YLNTIMKDQHEGGGGAGGVGGVGGGQVKGRSDPELGMLSSL----- 424
            .|....:.....|:|..| ::|....|.|          |||...::|.......:.|||
Zfish   485 MRPAKAAVTLEGKMEQALRWINNPGVDDH----------GVGQAAIRGLIAEGRRLASSLPGPYR 539

  Fly   425 EEL---CKQLVVSVSSQIEDFN------------------ESLK-ICSKL--------------- 452
            :||   |:| |..:..|:.|..                  |::| :.:|:
Zfish   540 QELLAKCEQ-VEQLMMQLADLAARGEGESPQARAVAAHLLEAIKDLKAKMQEAMTQEVSDVFSDT 603

  Fly   453 ---VKSFHVLAT------NYDIDNLNQRSSKFHDCCDHIFDICKLLQHIAPTERLQVQAKCLAI- 507
               :|...|.||      |.: :...:|:|.|.:....:....:....:....:..|:....|:
Zfish   604 TTPIKLLAVAATAPLEAPNRE-EVFEERASNFENHASRLGATAEKAAAVGTANKSTVEGIQAAVK 667

  Fly   508 NLRIYGPQVFIAAKILWKYSNSSAANENFESFSDMWKWLTNEISMIAKKILVSINTTKGDRDA-- 570
            :.|...|||..||:||.|...:.||.|:|::..:.|   .:.|..:...:..:|: ||...||
Zfish   668 SARDLTPQVTSAARILLKNPGNQAAYEHFDTMKNQW---IDNIEKMTSLVDEAID-TKSLLDASE 728

  Fly   571 -----DAEKC----------------------------------------------ESSSDKLTK 584
                 |.:||                                              :::||:|.:
Zfish   729 EAIKKDIDKCRVAMANVQPQMLVAGATSIARRANRVLLVAKREVENSEDPKFRELVKAASDELGR 793

  Fly   585 S---------GV----------------------------------------------------- 587
            :         ||
Zfish   794 TISPMVMAAKGVAGNIQDPGLQKGFLDSGYRILAAVGKVREAFQPQELDFPPPPPDLDQLHVNDD 858

  Fly   588 ----------------------------PATEDGEMVEY------------------------SG 600
                                        |..:.||||..                        .|
Zfish   859 QAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEMVSEPMMVAARSLHDEARKWSSKPEVPDEG 923

  Fly   601 LEG--------------KNNGD------------------------LNTYQSKWSEDLSDDNDIL 627
            .|.              .|..|                        |:....|||   |..|||:
Zfish   924 FEAAEAEVDIDDEDEFTDNEDDYEPELLLMSSNQPVNQPILAAAQSLHQEARKWS---SKGNDII 985

  Fly   628 KRAKNMSAMAFLMYQFTK----GNGSLRTTQDLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKK 688
            ..||.   ||.||.:.::    |:|:.|.   |...|:..|:.::.:.::.:..:.|......:.
Zfish   986 GAAKR---MALLMAEMSRLVRGGSGNKRA---LIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRT 1044

  Fly   689 DLLNILDRVPTFVQALQF--TVKDHTVGKA---------ATFVKVDHVIRETKNLMNVINKVVSK 742
            :||.:.:|:||....|:.  |||...:|:.         ||    :.::...:|||..:.:.|.:
Zfish  1045 NLLQVCERIPTISTQLKILSTVKATMLGRTNISEEESEQAT----EMLVHNAQNLMQSVKETVRE 1105

  Fly   743 CFECATKYKLNLTGIT 758
            ....:.|.:.: .|.|
Zfish  1106 AEAASIKIRTD-AGFT 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	38..755	CDD:460040	186/1116 (17%)
vcla	NP_001122153.1	Vinculin	3..1131	CDD:460040	188/1121 (17%)