Protein Alignment alpha-Catr and CTNNA3

DIOPT Version :10

• Sequence 1: NP_726389.4
• Gene: alpha-Catr / 49713
• FlyBaseID: FBgn0029105
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: XP_016871641.1
• Gene: CTNNA3 / 29119
• HGNCID: 2511
• Length: 970
• Species: Homo sapiens
• Alignment Length: 892
• Identity: 181/892 - (20%)
• Similarity: 320/892 - (35%)
• Gaps: 258/892 - (28%)

  Fly    46 GEIIAEENIDIKGDMYEAAKEARDAGK----SIERLCDISPLSGMELRHHIEP--LKDYGAIILA 104
            ||.||:|...:|.::..:.:|.|...:    |.||..|             :|  |....|::.|
Human    85 GEKIAQEATVLKDELTASLEEVRKESEALKVSAERFTD-------------DPCFLPKREAVVQA 136

  Fly   105 ARSLLSSVTRILLLVDIIVVKKLLTAKKRASESLEKLESVMNFTEFVRAFSVFGTEMIELAYLTG 169
            ||:||::|||:|:|.|:|.|..||........:.|.|::|.|.::..:.:...|.|:..|.||..
Human   137 ARALLAAVTRLLILADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAF 201

  Fly   170 HHR-----------------------NSFKEERRRAQMFSARQILEKSIAILLTSSKNSLIHSDC 211
            ..:                       :..|...:|.::..||..|:::..:|.:.....|.|||.
Human   202 KRQQVNNSGLNTTFAFSRKNLPTPKASDLKSPNQRDEIAGARASLKENSPLLHSICSACLEHSDV 266

  Fly   212 VIVKENRDTVFCQIRRAMDLIHFVVKDSIFDTAKHMPFEKQASNPNYENESIYTTIKRIVNLIKR 276
            ..:|.::|||..:|:.|:::|          :......:...:.|..:..::.:.:..:.|||..
Human   267 ASLKASKDTVCEEIQNALNVI----------SNASQGIQNMTTPPEPQAATLGSALDELENLIVL 321

  Fly   277 YKYQMSYYEGSGEGNNNSDAYFSFLDDDLWKS-EKNLPSAAGGGRMVNNTNFRKHLSSESLDLRE 340
            ....::                   ::::..| ||.|.:...|..::.:       ||.:.||..
Human   322 NPLTVT-------------------EEEIRPSLEKRLEAIISGAALLAD-------SSCTRDLHR 360

  Fly   341 ELSLAFEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEF---DLYL--------NTIMKDQHE 394
            |..:|......:|.....|.|: :|.||  |..|...:|..   .:||        :||....||
Human   361 ERIIAECNAIRQALQDLLSEYM-NNMRK--LIPCRATRLTKTAPQVYLTSGLVDSKSTISLLHHE 422

  Fly   395 GGGGAGGVGGVGGGQVKGRSDPELGMLSSLEELCK-------QLVVSVSSQIED-FNESLKICSK 451
            ...|.           |.||:.   :..:|:.:||       ||..::...:.| |.::......
Human   423 IKAGK-----------KERSNT---LNIALDNMCKKTRDLRRQLRKAIIDHVSDSFLDTTVPLLV 473

  Fly   452 LVKSFHVLATNYDIDNLNQRSSKFHDCCDHIFDICKLLQHIAPTERLQVQAKCLAINLRIYGPQV 516
            |:::    |.|.....:.:.::.||:....:.::..|...::..|......|..|.:|....||:
Human   474 LIEA----AKNGREKEIKEYAAIFHEHTSRLVEVANLACSMSTNEDGIKIVKIAANHLETLCPQI 534

  Fly   517 FIAAKILWKYSNSSAANENFESFSDMWK----WLT---NEISMIAKKILVSINTTKGD------- 567
            ..||..|.....|.|.....|.:...|:    .||   ::|:.|...:.||.:....|
Human   535 INAALALAARPKSQAVKNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSESHILEDVNKCIIA 599

  Fly   568 -RDADAEKCESSS---------------------------------------------------- 579
             ||.||:..:.::
Human   600 LRDQDADNLDRAAGAIRGRAARVAHIVTGEMDSYEPGAYTEGVMRNVNFLTSTVIPEFVTQVNVA 664

  Fly   580 -DKLTKSGVPATEDGEMVEYS-----------------------------------------GLE 602
             :.|:||.:...:|.:.|:.|                                         ..|
Human   665 LEALSKSSLNVLDDNQFVDISKKIYDTIHDIRCSVMMIRTPEELEDVSDLEEEHEVRSHTSIQTE 729

  Fly   603 GKNN-------------------GDLNTYQSKWSEDLS--DD--NDILKRAKNMSAMAFLMYQFT 644
            ||.:                   .|....:||...::.  ||  |||:..||||..:...|..||
Human   730 GKTDRAKMTQLPEAEKEKIAEQVADFKKVKSKLDAEIEIWDDTSNDIIVLAKNMCMIMMEMTDFT 794

  Fly   645 KGNGSLRTTQDLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQAL----Q 705
            :|.|.|:.|.|:...|:..:|..:|:..:.|..:.|.|....|:|||..|:::..:...|    |
Human   795 RGKGPLKHTTDVIYAAKMISESGSRMDVLARQIANQCPDPSCKQDLLAYLEQIKFYSHQLKICSQ 859

  Fly   706 FTVKDHTVGKAATFVKVDHV---IRETKNLMNVINKVVSKCFECATK 749
            ...:...:|.......:|.|   |:..|||||.:.:.|...:..:||
Human   860 VKAEIQNLGGELIMSALDSVTSLIQAAKNLMNAVVQTVKMSYIASTK 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	38..755	CDD:460040	181/892 (20%)
CTNNA3	XP_016871641.1	Vinculin	30..931	CDD:460040	181/892 (20%)