DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Catr and Ctnna2

DIOPT Version :9

Sequence 1:	NP_726389.4	Gene:	alpha-Catr / 49713	FlyBaseID:	FBgn0029105	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_001103234.1	Gene:	Ctnna2 / 12386	MGIID:	88275	Length:	953	Species:	Mus musculus

Alignment Length:	917	Identity:	194/917 - (21%)
Similarity:	352/917 - (38%)	Gaps:	256/917 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HLLNIAVER----FITIGEIIAEENIDIKGDMYEAAKEARDAGKSI----ERLCDISPLSGMELR 89
            |:|..:||:    |:..||.||:|:.|:|.::..|.::.|..|:::    ....| .|.|.::
Mouse    58 HVLAASVEQATQNFLEKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFAD-DPCSSVK-- 119

  Fly    90 HHIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESLEKLESVMNFTEFVRAF 154
                    .|.::.|||:|||:|||:|:|.|:..|.:||:..|...|:||.:::..|..:....|
Mouse   120 --------RGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRF 176

  Fly   155 SVFGTEMIELAYLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTSSKNSLIHSDCVIVKENRD 219
            ..||.||::|.|:....:...|:...|.:|.:||..|:|:..:|.|:|:..|.|.|....:.|||
Mouse   177 KEFGKEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRANRD 241

  Fly   220 TVFCQIRRAMDLIHFVVKDSIFDTAKHMPFEKQASNPNYENESIYTTIKRIVNLIKRYKYQ---- 280
            .||.|::.|:..|....               ||::|..|.:. :|.|..:...:..:..:
Mouse   242 YVFKQVQEAIAGISSAA---------------QATSPTDEAKG-HTGIGELAAALNEFDNKIILD 290

  Fly   281 -MSYYEGSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGGGRMVNNTNF-----RKHLSSESLDLR 339
             |::          |:|.|.      ...|:.|.|...|..::.:::.     |:.:.:|...:|
Mouse   291 PMTF----------SEARFR------PSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVR 339

  Fly   340 --------------------EELSLAFEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLY 384
                                :.|::|.:|:.:|..|      :....||.::.:..:..||.::.
Mouse   340 QALQDLLSEYMNNTGRKEKGDPLNIAIDKMTKKTRD------LRRQLRKAVMDHISDSFLETNVP 398

  Fly   385 LNTIMKDQHEGGGGAGGVGGVGGGQVK---------------------GRSDPELGM------LS 422
            |..:::....|          ...:||                     ..|:.|.|:      .:
Mouse   399 LLVLIEAAKSG----------NEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAAT 453

  Fly   423 SLEELCKQLV------------------------------------VSVSSQIEDF-----NESL 446
            .::.||.|::                                    |...:.::||     |..|
Mouse   454 QIDSLCPQVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHIL 518

  Fly   447 KICSKLVKSFHVLATNYDIDNLNQRSSKFHD--------------------CCDHIFDICKLL-Q 490
            :..:|.|    :.....|:|.|::.:.....                    ..:.:.:..||| :
Mouse   519 EDVNKCV----IALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSE 579

  Fly   491 HIAP--TERLQVQAKCLAINLRIYGPQVFIAAKILWKYSNSSAANENFESFSDMWKWLTNEISMI 553
            .:.|  .|:::|..:.|:.|:    ||.|               .||  .|.|..:.:.:.:..|
Mouse   580 TVMPRFAEQVEVAIEALSANV----PQPF---------------EEN--EFIDASRLVYDGVRDI 623

  Fly   554 AKKILVSINTTKGDRDADAEK----------CESSSDKL--------TKSGVPATEDGEMVEYSG 600
            .|.:|:.....:.:.|:|.|:          .::..|:|        ..:.:|..|..::.|...
Mouse   624 RKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVE 688

  Fly   601 LEGKNNGDLNTYQSKWSEDLSDDNDILKRAKNMSAMAFLMYQFTKGNGSLRTTQDLFTQAEYFAE 665
            :..:....|:...:||.:   ..|||:..||.|..:...|..||:|.|.|:.|.|:...|:..||
Mouse   689 IFHQEKSKLDAEVAKWDD---SGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAE 750

  Fly   666 EANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQALQFTVKDHTVGKAATFVKVDHVIRETK 730
            ..:|:.|:.|..:.|.|.|..|:|||..|.|:..:...|....|               |..|.:
Mouse   751 AGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSK---------------VKAEVQ 800

  Fly   731 NL---MNVINKVVSKCFECATKYKLNLTGITGGLTSERSNE--NMAGGMCDSKGTTSSSDIPXHY 790
            ||   :.|....|...|  .|.|:::...|.||..|:.|..  ..|.|.....|::.||.:....
Mouse   801 NLGGELIVSGTGVQSTF--TTFYEVDCDVIDGGRASQLSTHLPTCAEGAPIGSGSSDSSMLDSAT 863

  Fly   791 GMARRAK 797
            .:.:.||
Mouse   864 SLIQAAK 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	52..755	CDD:279395	173/848 (20%)
Ctnna2	NP_001103234.1	Vinculin	81..914	CDD:395830	185/894 (21%)
Ctnna2	NP_001103234.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810