DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Catr and Ctnna1

DIOPT Version :9

Sequence 1:	NP_726389.4	Gene:	alpha-Catr / 49713	FlyBaseID:	FBgn0029105	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_033948.1	Gene:	Ctnna1 / 12385	MGIID:	88274	Length:	906	Species:	Mus musculus

Alignment Length:	945	Identity:	195/945 - (20%)
Similarity:	329/945 - (34%)	Gaps:	293/945 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HLLNIAVER----FITIGEIIAEENIDIKGDMYEAAKEARDAG---KSIERLCDISPLSGMELRH 90
            |:|..:||:    |:..|:.||:|:..:|.::..|.::.|..|   ||........|.|.::
Mouse    59 HVLAASVEQATENFLEKGDKIAKESQFLKEELVVAVEDVRKQGDLMKSAAGEFADDPCSSVK--- 120

  Fly    91 HIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESLEKLESVMNFTEFVRAFS 155
                   .|.::.|||:|||:|||:|:|.|:..|.|||...|...:.:.||.:..|..:....:.
Mouse   121 -------RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYK 178

  Fly   156 VFGTEMIELAYLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTSSKNSLIHSDCVIVKENRDT 220
            ....|:.:|..:....:...|:...|.||.:||.||:|::.||.|:|:..|.|.|....|.|||.
Mouse   179 ALKPEVDKLNIMAAKRQQELKDVGNRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDL 243

  Fly   221 VFCQIRRAMDLIHFVVKDSIFDTAKHMPFEKQASNPNYENESIYTTIKRIVNLIKRYKYQMSYYE 285
            ::.|:::|:..|
Mouse   244 IYKQLQQAVTGI----------------------------------------------------- 255

  Fly   286 GSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGGGRMVNNTNFRKHLSSESLDLREE-----LSLA 345
                    |:|..:...||..:.:    ..:||.......||.|.:..:.|...||     |...
Mouse   256 --------SNAAQATASDDAAQHQ----GGSGGELAYALNNFDKQIIVDPLSFSEERFRPSLEER 308

  Fly   346 FEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLYLNTIMKDQHEGGGGAGGVGGVGGGQV 410
            .|.:...|....||.....:.|:.|::.|:..:......|:..|       |.||.
Mouse   309 LESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYM-------GNAGR--------- 357

  Fly   411 KGRSDPELGMLSSLEELCK-------QLVVSVSSQIED-FNESLKICSKLVKSFHVLATNYDIDN 467
            |.|||   .:.|:::::.|       ||..:|...:.| |.|:......|:::    |.|.:...
Mouse   358 KERSD---ALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEA----AKNGNEKE 415

  Fly   468 LNQRSSKFHDCCDHIFDICKLLQHIAPTERLQVQAKCLAINLRIYGPQVFIAAKILWKYSNSSAA 532
            :.:.:..|.:..:.:.::..|...|:..|......:..|..|....|||..||..|.....|..|
Mouse   416 VKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA 480

  Fly   533 NENFESFSDMW----KWLT---NEISMIAKKILVSINTTKGD----------RDAD--------- 571
            .||.:.|.:.|    :.||   ::|:.|...:.||.|....|          :|.|
Mouse   481 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAI 545

  Fly   572 ------------------------------------------AEKCESSSDKLTKSGVPATEDGE 594
                                                      .|:.|::.:.|:.......::.|
Mouse   546 RGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENE 610

  Fly   595 MVE-----YSGL-------------EGKNNGDLNT----YQSKWSEDLSDD-------------- 623
            .::     |.|:             |..::.|..|    .:|:.|....||
Mouse   611 FIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQ 675

  Fly   624 ----------------------------------NDILKRAKNMSAMAFLMYQFTKGNGSLRTTQ 654
                                              |||:..||.|..:...|..||:|.|.|:.|.
Mouse   676 LPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS 740

  Fly   655 DLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQALQFTVK----DHTVGK 715
            |:.:.|:..||..:|:.|:.|..:...|.|..|:|||..|.|:..:...|....|    ...:|.
Mouse   741 DVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGG 805

  Fly   716 AATFVKVD---HVIRETKNLMNVINKVVSKCFECATKYK-------LNLTGITGGLTSERSNENM 770
            ......||   .:|:..|||||.:.:.|...:..:|||:       |||..::..:.:
Mouse   806 ELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKA------- 863

  Fly   771 AGGMCDSKGTTSSSDIPXHYGMARRAKGDARRTRV 805
                            |....:.:|.|.|..:|::
Mouse   864 ----------------PEKKPLVKREKQDETQTKI 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	52..755	CDD:279395	181/870 (21%)
Ctnna1	NP_033948.1	Involved in homodimerization. /evidence=ECO:0000250	2..228		53/178 (30%)
		Vinculin	19..867	CDD:366435	191/928 (21%)
		Interaction with JUP and CTNNB1. /evidence=ECO:0000250	97..148		19/60 (32%)
		Interaction with alpha-actinin. /evidence=ECO:0000250	325..394		18/87 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..894		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810