Protein Alignment alpha-Catr and vclb

DIOPT Version :10

• Sequence 1: NP_726389.4
• Gene: alpha-Catr / 49713
• FlyBaseID: FBgn0029105
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: NP_001304681.1
• Gene: vclb / 100334859
• ZFINID: ZDB-GENE-131017-1
• Length: 1066
• Species: Danio rerio
• Alignment Length: 1061
• Identity: 163/1061 - (15%)
• Similarity: 323/1061 - (30%)
• Gaps: 395/1061 - (37%)

  Fly    38 AVERFITIGE--IIAEENIDIKGDMYEAAKEARDAGKSIERLCDISPLSGMELRHHIEPLKDYGA 100
            ||...:.:|:  :...|:..::.||..|..:..:|...:.:...:     ::...:..|.:||
Zfish    50 AVSNLVRVGKETVQTTEDAIMRRDMPPAFIKVENACTKLVQAAQM-----LKADPYSVPARDY-- 107

  Fly   101 IILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESLEKLESVMNFTEFVRAFSVFGTEMIELA 165
            :|..:|.:||..:.:||..|...|:|::...|...|.|...|.|.:..:.:......|..|.::|
Zfish   108 LIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVESMEDLITYTKNLGPGMTKMA 172

  Fly   166 YLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTSSKNSLIHSDCVIVKENRDTVFCQIRRAMD 230
            .:....:.....:..|..:.::...:::.:.:|::..|                 :|...|
Zfish   173 KMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISGIK-----------------IFVTTR---- 216

  Fly   231 LIHFVVKDSIFDTAKHMPFEKQASNPNYENESIYTTIKRIVNLIKRYKYQMSYYEGSGEGNNNSD 295
                        |::....|:...|.|:..|.:.|.|..|:.::     |::.::.....|.:::
Zfish   217 ------------TSQGKGVEEALKNRNFTVEKMNTEINEIIRVL-----QLTSWDEDAWANKDTE 264

  Fly   296 AY---FSFLDDDL-----W---------------------KSEKNLPSAAGGGR--MVNNTNFRK 329
            |.   .:.:|..:     |                     ::||.....||..|  :|.......
Zfish   265 AMKRALALIDSKMAQAKNWLRDPQGQPGGPGEQAIRQILDEAEKVGELCAGKERRDIVGTAKTLG 329

  Fly   330 HLSSESLDLR--------------EELS------------------------LAFEKLFEKAHDF 356
            .|:.:..|||              :::|                        .|..|..:.|..:
Zfish   330 QLTEQVSDLRARGQGANPVAMQKAQQVSQGLDVLTGKVENAARKLEAMTGSKQAIAKRIDAAQSW 394

  Fly   357 TDSPYISHNHRKN----------ILSYCDNCKLEFDLY--------LNTIMKDQHEGGGG----- 398
            ...|:......:|          |...|::.|...|:.        |:..:.:....|.|
Zfish   395 LADPHSGPEGEENIRALLGEARKIADLCEDPKEREDILRSMSEIAALSGKLAELKRAGKGDTPEA 459

  Fly   399 ----------------------------------AGGV--------------GGVGGGQVKG--- 412
                                              ||.:              .|||...::|
Zfish   460 RALAKQIATALQNLQSKTSKAVANTRPAKAAVHLAGKMEQAGRWIDNPTLDDSGVGQAAIRGLLA 524

  Fly   413 ------------RSDPELGMLSSLEELCKQLVVSVSSQIEDFNESLKICSKL------------- 452
                        :....||....:|.|..||....:....|..::..|..:|
Zfish   525 EGRRLANALPAAQRQELLGKCEQVEHLMAQLAELAARGEGDSPQARAIAQQLQHTLKELEGKMQD 589

  Fly   453 ----------------VKSFHVLAT-NYDIDN----LNQRSSKFHDCCDHIFDICKLLQHIAPTE 496
                            :|...|.|| ..|..|    ..:|:|.|.:....:....:....:....
Zfish   590 AMTQEVSDIFSDTTTPIKLLAVAATAPSDSPNREEVFKERASNFENHASRLGATAEKAAAVGTAN 654

  Fly   497 RLQVQAKCLAI-NLRIYGPQVFIAAKILWKYSNSSAANENFESFSDMWKWLTNEISMIAKKILVS 560
            :..|:....|: :.|...|||..||:||.|...:.||.|:||:..:.|.....:::.:..:.:.:
Zfish   655 KSTVEGIQAAVKSARDLTPQVVSAARILLKNPGNQAAFEHFETMKNQWIDNVEKLTGLVDEAIDT 719

  Fly   561 INTTKGDRDA---DAEKCE---------------------------------------------- 576
            .:......||   |.:||:
Zfish   720 RSLLAASEDAIKKDLDKCQVAMANHQPQMLVAGATSIARRANRILLVAKREIENSEDPKFRETVK 784

  Fly   577 SSSDKLTKSGVPATEDGEMV----EYSGLEG--KNNG--------------------------DL 609
            ::||:|:::..|...|.:.|    :..||:.  .::|                          ||
Zfish   785 AASDELSRTISPMVMDAKAVAANIKDQGLQRGFLDSGFKILGAVANVRDAFQPQEPEFPPPPPDL 849

  Fly   610 NTYQ--------------------------------------------------------SKWSE 618
            .:.|                                                        .|||
Zfish   850 ESLQISDTAAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQQAGEMVSEPMMVAARQLHDEARKWS- 913

  Fly   619 DLSDDNDILKRAKNMSAMAFLMYQFTKGNGSLRTTQDLFTQAEYFAEEANRLYKVLRHFSYQVPA 683
              |..|||:..||.|:.:...|.:..:|:|.  ..:.|...|:..|:.::.:.::.:..:.|...
Zfish   914 --SKGNDIIGAAKRMALLMAEMSRLVRGSGG--NKRALIQCAKDIAKASDEVTRLAKEVAKQCTD 974

  Fly   684 SDNKKDLLNILDRVPTFVQALQF--TVKDHTVGKA---------ATFVKVDHVIRETKNLMNVIN 737
            ...:.:||.:.:|:||....|:.  |||...:|:.         ||    :.::...:|||..:.
Zfish   975 KRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISEEESEQAT----EMLVHNAQNLMQSVK 1035

  Fly   738 KVVSKCFECATKYKLNLTGIT 758
            :.|.:....:.|.:.: .|.|
Zfish  1036 ETVREAEAASIKIRTD-AGFT 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	38..755	CDD:460040	161/1056 (15%)
vclb	NP_001304681.1	Vinculin	3..1066	CDD:460040	163/1061 (15%)
		MukB	296..>588	CDD:442330	38/291 (13%)