DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gish and YCK3

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_011049.2	Gene:	YCK3 / 856860	SGDID:	S000000925	Length:	524	Species:	Saccharomyces cerevisiae

Alignment Length:	526	Identity:	199/526 - (37%)
Similarity:	268/526 - (50%)	Gaps:	105/526 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 MVGPNFRVGKKIGCGNFGELRLGKNLYN-----------------NEHVAIKMEPMKSKAPQLHL 104
            :||.::.||.|||.|:||.:..|:|:.:                 ||.||||.||..|.||||..
Yeast     9 IVGIHYAVGPKIGEGSFGVIFEGENILHSCQAQTGSKRDSSIIMANEPVAIKFEPRHSDAPQLRD 73

  Fly   105 EYRFYKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAK 169
            |:|.|::|     |...|||..|:.|. .|.:|.::::|||.||||||..|.||||:||..|:||
Yeast    74 EFRAYRIL-----NGCVGIPHAYYFGQ-EGMHNILIIDLLGPSLEDLFEWCGRKFSVKTTCMVAK 132

  Fly   170 QLLHRIEYVHSRHLIYRDVKPENFLIGR----------------TSTKREKIIHIIDFGLAKEYI 218
            |::.|:..:|...|||||:||:||||.:                :|.....:|:::|||:||:|.
Yeast   133 QMIDRVRAIHDHDLIYRDIKPDNFLISQYQRISPEGKVIKSCASSSNNDPNLIYMVDFGMAKQYR 197

  Fly   219 DLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLK 283
            |..|.:||||||.|||:|||||||||||.|||||||||||:|||:|.||||||||||||||...|
Yeast   198 DPRTKQHIPYRERKSLSGTARYMSINTHFGREQSRRDDLESLGHVFFYFLRGSLPWQGLKAPNNK 262

  Fly   284 ERYQKIGDTK-RATPIEVLCDGH-PEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDE 346
            .:|:|||.|| :..|.::|.:.. |.:|||||:|.|.|.|.|.||||:|..|..|........|:
Yeast   263 LKYEKIGMTKQKLNPDDLLLNNAIPYQFATYLKYARSLKFDEDPDYDYLISLMDDALRLNDLKDD 327

  Fly   347 GEFDWT----GKTMSTPVGSLQTGH-----EVIISPNKDRHNVTAKTNAKGGVAAWPDVPKPGAT 402
            |.:||.    ||..:..:......|     ...::.|..|:||  .||:|
Yeast   328 GHYDWMDLNGGKGWNIKINRRANLHGYGNPNPRVNGNTARNNV--NTNSK--------------- 375

  Fly   403 LGNLTPADRHGSVQVVSSTNGELNPDDPTAGHSNTP--ITQQPEVEVVDETKCCCFFKRKKKKST 465
            ..|.||.     ...........|.|:..:..|:.|  .|:|..|              .||...
Yeast   376 TRNTTPV-----ATPKQQAQNSYNKDNSKSRISSNPQSFTKQQHV--------------LKKIEP 421

  Fly   466 RQKXLDGVQCSPEREAVTLLRATSHSNSRDSVLNNPSQDYIQQATSQHTLRYPPSASMLTPTPTT 530
            ..|.:      ||          :|||.:..: .:.||.|...:.:|::...|.|:|...|..:.
Yeast   422 NSKYI------PE----------THSNLQRPI-KSQSQTYDSISHTQNSPFVPYSSSKANPKRSN 469

  Fly   531 NTPTLP 536
            |...||
Yeast   470 NEHNLP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	158/331 (48%)
		S_TKc	62..335	CDD:214567	153/307 (50%)
		CK1gamma_C	354..428	CDD:289378	13/78 (17%)
YCK3	NP_011049.2	PKc_like	13..320	CDD:419665	154/312 (49%)
YCK3	NP_011049.2	ROM1	361..>479	CDD:227709	36/168 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344355
Domainoid	1	1.000	257	1.000	Domainoid score	I319
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I438
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R203
SonicParanoid	1	1.000	-	-		X651
TreeFam	0	0.000	Not matched by this tool.
	9	8.920