DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and HRR25

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_015120.1	Gene:	HRR25 / 855897	SGDID:	S000006125	Length:	494	Species:	Saccharomyces cerevisiae

Alignment Length:	518	Identity:	200/518 - (38%)
Similarity:	278/518 - (53%)	Gaps:	85/518 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 120
            |.||..||:|:|||.|:||::..|.||.:.|.||||:|.::|:.|||..|.|.|:.|....
Yeast     3 LRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRSRHPQLDYESRVYRYLSGGV---- 63

  Fly   121 DGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIY 185
             |||.|...|. .|.|||||::|||.|||||||.|.|:||.|||:|:|.|:..||:|:|.|..|:
Yeast    64 -GIPFIRWFGR-EGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIH 126

  Fly   186 RDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGRE 250
            ||:||:|||:|  ..:|...:|:|||||:|:|.|.:|:|||||||:|||||||||.|:|||:|.|
Yeast   127 RDIKPDNFLMG--VGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIE 189

  Fly   251 QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRY 315
            ||||||||:||::.:||.:||||||||||.|.|::|.:|.:.|....:|.||.|.|.||..|:.|
Yeast   190 QSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGLPLEFQEYMAY 254

  Fly   316 VRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWT----GKTMSTPVGSLQTGHEVIISPNKD 376
            .:.|.|.|.|||.||.|||:||..:..|.::..||||    .|.|      ::...:::|    :
Yeast   255 CKNLKFDEKPDYLFLARLFKDLSIKLEYHNDHLFDWTMLRYTKAM------VEKQRDLLI----E 309

  Fly   377 RHNVTAKTNAKGGVAAWPDVPKPGATLGNL---------------------TPADRHGSVQVVSS 420
            :.::.|.:||   .:|.........|...:                     .|:......|.:.:
Yeast   310 KGDLNANSNA---ASASNSTDNKSETFNKIKLLAMKKFPTHFHYYKNEDKHNPSPEEIKQQTILN 371

  Fly   421 TNGE-------LNPDDPTAGHSNTPITQQPEVEVVDETKCCCFFKRKKKKSTRQKXLDGVQCSPE 478
            .|..       ||..|  .|..|.. .|||:.:|              :.|..|. ...:|..|.
Yeast   372 NNAASSLPEELLNALD--KGMENLR-QQQPQQQV--------------QSSQPQPQPQQLQQQPN 419

  Fly   479 REAVT-----LLRATSHSNSRDSVLNNPSQDYIQQATSQHTLRYPPSASMLTPTPTTNTPTLP 536
            .:...     ||:    ...|||   ...|..:..||::.| :|||..:  :....||..::|
Yeast   420 GQRPNYYPEPLLQ----QQQRDS---QEQQQQVPMATTRAT-QYPPQIN--SNNFNTNQASVP 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	158/296 (53%)
		S_TKc	62..335	CDD:214567	150/272 (55%)
		CK1gamma_C	354..428	CDD:289378	13/101 (13%)
HRR25	NP_015120.1	PKc_like	8..282	CDD:419665	153/281 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810