Protein Alignment gish and YCK2

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_014245.1
• Gene: YCK2 / 855568
• SGDID: S000005098
• Length: 546
• Species: Saccharomyces cerevisiae
• Alignment Length: 535
• Identity: 211/535 - (39%)
• Similarity: 289/535 - (54%)
• Gaps: 79/535 - (14%)

  Fly    20 PSAGNVANATTALAGGKSSSNNMYSTRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYN 84
            |.:.:|::......|..|:|   ||..||...:|   :||.::::|||||.|:||.|..|.|:.|
Yeast    40 PPSLHVSSNLNHNTGNSSAS---YSGSQSRDDST---IVGLHYKIGKKIGEGSFGVLFEGTNMIN 98

  Fly    85 NEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLE 149
            ...||||.||.|::||||..|||.||:|.     ...|||:.|:.|. .|.:|.:|::|||.|||
Yeast    99 GLPVAIKFEPRKTEAPQLKDEYRTYKILA-----GTPGIPQEYYFGQ-EGLHNILVIDLLGPSLE 157

  Fly   150 DLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLA 214
            |||:.|.|:||:|||:.:|.|::..||.:|:..|||||:||:||||||........:|:||||:|
Yeast   158 DLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANKVHLIDFGMA 222

  Fly   215 KEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKA 279
            |:|.|..|.:||||||.|||:|||||||||||:|||||||||:||:||:|.|||||.||||||||
Yeast   223 KQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEAMGHVFFYFLRGQLPWQGLKA 287

  Fly   280 DTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYT 344
            ...|::|:|||:.||.|.:..|..|.|.:|..||..||.|.|.|||||:..|.|...:.|..|.|
Yeast   288 PNNKQKYEKIGEKKRLTNVYDLAQGLPIQFGRYLEIVRNLSFEETPDYEGYRMLLLSVLDDLGET 352

  Fly   345 DEGEFDWTGKTMSTPVGSLQTGHEVIISPNKDRHNVTAKTNAKGGVAAWPDVPKPGATLGNLTPA 409
            .:|::||.         .|..|....:|.||       |.|..|  ...|:.|.        ..:
Yeast   353 ADGQYDWM---------KLNGGRGWDLSINK-------KPNLHG--YGHPNPPN--------EKS 391

  Fly   410 DRHGSVQVVSSTNGELNPDDPTAGHSNTPITQQPEVEVVDETKCCCFFKRKK-KKSTRQKXLDGV 473
            .||      .|.|.:.:  .|...|......||.:.:...:.:.....:::: :::..|:..:..
Yeast   392 KRH------RSKNHQYS--SPDHHHHYNQQQQQQQAQAQAQAQAQAKVQQQQLQQAQAQQQANRY 448

  Fly   474 QCSP-------EREAVTLLRATSHSNSRDSVLNNPSQDYIQQATSQ---------------HTLR 516
            |..|       |||| :.|..||:    ::......|.|.||...|               .|.:
Yeast   449 QLQPDDSHYDEEREA-SKLDPTSY----EAYQQQTQQKYAQQQQKQMQQKSKQFANTGANGQTNK 508

  Fly   517 YPPSASMLTPTPTTN 531
            ||.:|.     ||.|
Yeast   509 YPYNAQ-----PTAN 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	159/292 (54%)
		CK1gamma_C	354..439	CDD:463640	16/84 (19%)
YCK2	NP_014245.1	STKc_CK1_fungal	75..351	CDD:271029	154/281 (55%)