DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gish and CKL13

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_171939.1	Gene:	CKL13 / 839520	AraportID:	AT1G04440	Length:	468	Species:	Arabidopsis thaliana

Alignment Length:	494	Identity:	197/494 - (39%)
Similarity:	296/494 - (59%)	Gaps:	58/494 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 MVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPD 121
            :||..|::|:|:|.|:|||:.||.|:...|.||:|:||::::.||||.|.:.|.||     ....
plant     4 VVGGKFKLGRKLGSGSFGEIFLGVNVQTGEEVAVKLEPLRARHPQLHYESKLYMLL-----QGGT 63

  Fly   122 GIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYR 186
            |||.:...|. .|.:|.||::|||.|:|:.||.|:|.||||||||:|.|:::|:||:|.:..::|
plant    64 GIPHLKWFGV-EGEFNCMVIDLLGPSMEEFFNYCSRSFSLKTVLMLADQMINRVEYMHVKGFLHR 127

  Fly   187 DVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQ 251
            |:||:|||:|  ..::...::|||:||||:|.||.|::||||||:|:|||||||.|:|||:|.||
plant   128 DIKPDNFLMG--LGRKANQVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGIEQ 190

  Fly   252 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYV 316
            |||||||:||::.|||||||||||||:|.|.|::|.||.:.||.||:||||...|.||.:|..||
plant   191 SRRDDLESLGYLLMYFLRGSLPWQGLRAGTKKQKYDKISEKKRLTPVEVLCKNFPPEFTSYFLYV 255

  Fly   317 RRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTGKTMSTPVGSLQTGHEVIISPNKDRHNVT 381
            |.|.|.:.|||.:|:|||:|||.|:||..:..||||                ::..|   :...:
plant   256 RSLRFEDKPDYSYLKRLFRDLFIREGYQFDYVFDWT----------------ILRYP---QFGSS 301

  Fly   382 AKTNAKGGVAAWP--DVPKPGATLGNLTPADR------HGSVQVVSSTNGELNPDDPTAGHSNTP 438
            :.:|:|......|  ::|.|.|......|..:      .|..:..:..||  :.....|..|:.|
plant   302 SSSNSKPRPTLRPAMNIPVPSADKAEKPPIGQDSRERFSGVFEAYTRRNG--SGTGVQADQSSRP 364

  Fly   439 ITQQPEVEVVDETKCCCFFKRKKKKSTRQKXLDGVQCSPEREAV--TLLRATSHSNSRDSVLNN- 500
            .|.:..:...|.       :.:::.::..:.|     |..|:|:  :.:||||.::..::.|:.
plant   365 RTSENVLASKDT-------QNQERPNSLSRNL-----SSSRKAIAGSSVRATSSADFTENRLSRL 417

  Fly   501 -PSQDYIQQATSQHTLRYPPSASMLT---PTPTTNTPTL 535
             |:.|  :.:|:..|...|.|:|:.|   ||......||
plant   418 IPNND--RSSTTLRTQFAPSSSSVATKAAPTRAARDITL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	158/292 (54%)
		S_TKc	62..335	CDD:214567	147/272 (54%)
		CK1gamma_C	354..428	CDD:289378	11/81 (14%)
CKL13	NP_171939.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	152/281 (54%)
CKL13	NP_171939.1	Pkinase	9..241	CDD:278497	130/239 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910