Protein Alignment gish and ttbk2

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: XP_012824152.2
• Gene: ttbk2 / 780299
• XenbaseID: XB-GENE-493335
• Length: 1298
• Species: Xenopus tropicalis
• Alignment Length: 552
• Identity: 148/552 - (26%)
• Similarity: 230/552 - (41%)
• Gaps: 128/552 - (23%)

  Fly    56 LMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 120
            ::|...::|.:|||.|.|||:....:|...|:||:|:|..:.....|.:|....|.|
 Frog    15 ILVKERWKVLRKIGGGGFGEIYDALDLLTRENVALKVESAQQPKQVLKMEVAVLKKL-------- 71

  Fly   121 DGIPRIYHLGTCG--GRYNAMVLELLGLSLEDLFNICAR-KFSLKTVLMIAKQLLHRIEYVHSRH 182
            .|...:.....||  .|:|.:|::|.|.:|.||....:| .||:.|:|.:.:|:|..||.:||..
 Frog    72 QGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFSISTMLRLGRQILESIESIHSVG 136

  Fly   183 LIYRDVKPENFLIGR-TSTKREKIIHIIDFGLAKEYIDL--DTNRHIPYREHKSLTGTARYMSIN 244
            .::||:||.||.:|| .||.|:  .:::|||||:::.:.  |..   |.|......||.||.|:|
 Frog   137 FLHRDIKPSNFAMGRFPSTCRK--CYMLDFGLARQFTNSCGDVR---PPRAVAGFRGTVRYASVN 196

  Fly   245 THMGREQSRRDDLEALGHMFMYFLRGSLPWQGLK----ADTLKERYQKIGDTKRATPIEVLCDGH 305
            .|..||..|.|||.:|.:|.:.|:.|.|||:.:|    ..::||||:.          .::....
 Frog   197 AHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYEH----------RLMLKHL 251

  Fly   306 PEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDW----------TGKTMSTP- 359
            |.||:.:|.::..||:|..|||..|..:|.:.....|..:...|||          |..|.:||
 Frog   252 PPEFSVFLEHIIGLDYFTKPDYQLLVSVFDNSMKTFGVLESDPFDWEKSGSDGSLITTTTSTTPQ 316

  Fly   360 ------------------VGSL-----------------QTGHEVIISPNK----DRHNVTAKTN 385
                              .|.|                 :.|..||:||.|    ..|....:.:
 Frog   317 LHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQFSDGENGIPVIVSPEKLPGSPNHQRLQEKD 381

  Fly   386 AKGGVAAWP--DVPKPGATLGNLTPADRHGSVQVVSSTNGELNPDDPTAGHSNTPI------TQQ 442
                  .|.  |..:....:|....|...      .::||:.|...|:.|   :||      .|.
 Frog   382 ------VWEEMDANRNKIKMGICKAATED------ENSNGQGNGHAPSLG---SPIRVRSETAQD 431

  Fly   443 PEVEVVDETKCCCFFKRKKK-----KSTRQKXLDGVQCSPEREAVT--LLRATSHSNSRDSVLNN 500
            .:|.::.:.:....|:.:::     |....|.||.....|:||..|  .|...|.::.|.|....
 Frog   432 RDVPLLRKLRTIHSFELERRMTLESKPDADKFLDNCPEKPQRETNTGGPLAEGSCASPRQSKKTV 496

  Fly   501 PSQDYIQQATSQHTLRY----------PPSAS 522
            |     ..|.:.|...|          |.|||
 Frog   497 P-----PTAQADHAWHYDDEYIPEGSKPGSAS 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	101/312 (32%)
		CK1gamma_C	354..439	CDD:463640	21/126 (17%)
ttbk2	XP_012824152.2	Protein Kinases, catalytic domain	20..281	CDD:473864	95/283 (34%)