Protein Alignment gish and VRK2

DIOPT Version :9

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001123952.1
• Gene: VRK2 / 7444
• HGNCID: 12719
• Length: 508
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 127/515 - (24%)
• Similarity: 192/515 - (37%)
• Gaps: 118/515 - (22%)

  Fly    57 MVGPNFRVGKKIGCGNFGELRL----GKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHAD 117
            |.|..:.:|||||.|.||.:.|    .|...:..|| :|:| .:...| |..|.:||:.:..
Human    24 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHV-VKVE-YQENGP-LFSELKFYQRVAK--- 82

  Fly   118 NAPD--------------GIPRIYHLGTC---GGRYNAMVLELLGLSLEDLFNICARK--FSLKT 163
              .|              |||..|..|..   |..|..||:|.||:   ||..|..:.  |...|
Human    83 --KDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGI---DLQKISGQNGTFKKST 142

  Fly   164 VLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPY 228
            ||.:..::|..:||:|....::.|:|..|.|:|   .|....:::.|:||:..|  .....|..|
Human   143 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG---YKNPDQVYLADYGLSYRY--CPNGNHKQY 202

  Fly   229 REH--KSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPW----------QGLKADT 281
            :|:  |...||..:.|::.|.|...|||.|:|.||:..:.:|.|.|||          |..|.:.
Human   203 QENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNL 267

  Fly   282 LKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDE 346
            |.|..|.:  .|.|......|     |.|.:|.....|.:.|.|:|..|:::.
Human   268 LDELPQSV--LKWAPSGSSCC-----EIAQFLVCAHSLAYDEKPNYQALKKIL------------ 313

  Fly   347 GEFDWTGKTMSTPVGSLQ---TGHEV-IISPNKDRHNVTAKTNAKGGVAAWPDVPKPGATLGNLT 407
                   .....|:|.|.   .|..: :.:||..:        .....||...|.|   ....|.
Human   314 -------NPHGIPLGPLDFSTKGQSINVHTPNSQK--------VDSQKAATKQVNK---AHNRLI 360

  Fly   408 PADRHGSVQVVSSTNGELNPDDPTAGHSNTPITQQPEVEVVDETKCCCFFKRKKKKSTRQKXLDG 472
            ....|......|....::..::...|..|....|:..             :|::|....|: |:.
Human   361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQEST-------------RRRQKYQESQEPLNE 412

  Fly   473 VQCSPEREAVTLLRATSHSNSRDSVLNNPSQDYIQQATSQHTLRYPPSASMLTPTPTTNT 532
            |...|::     :..|...||    ...|.||:    ||....:...|.|....|.|.:|
Human   413 VNSFPQK-----ISYTQFPNS----FYEPHQDF----TSPDIFKKSRSPSWYKYTSTVST 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	90/327 (28%)
		S_TKc	62..335	CDD:214567	90/307 (29%)
		CK1gamma_C	354..428	CDD:289378	13/77 (17%)
VRK2	NP_001123952.1	STKc_VRK2	16..314	CDD:271025	92/331 (28%)
		SPS1	29..421	CDD:223589	112/462 (24%)
		Interaction with MAP3K7. /evidence=ECO:0000269|PubMed:17709393	397..508		19/89 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810