DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and Csnk1g3

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_006526293.1	Gene:	Csnk1g3 / 70425	MGIID:	1917675	Length:	456	Species:	Mus musculus

Alignment Length:	446	Identity:	308/446 - (69%)
Similarity:	355/446 - (79%)	Gaps:	22/446 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KSSSNNMYSTRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAP 100
            :.|..:.:|||.:.|:::||||||||||||||||||||||||||||||.||:||||:|||||:||
Mouse    17 RPSGRSGHSTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAP 81

  Fly   101 QLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVL 165
            ||||||||||.|||     .||||::|:.|.| |:||||||||||.||||||::|.|.|||||||
Mouse    82 QLHLEYRFYKQLGS-----GDGIPQVYYFGPC-GKYNAMVLELLGPSLEDLFDLCDRTFSLKTVL 140

  Fly   166 MIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYRE 230
            |||.||:.|:|||||::|||||||||||||||...|.:::||||||||||||||.:|.:||||||
Mouse   141 MIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKAQQVIHIIDFGLAKEYIDPETKKHIPYRE 205

  Fly   231 HKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRA 295
            ||||||||||||||||:|:||||||||||||||||||||||||||||||||||||||||||||||
Mouse   206 HKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRA 270

  Fly   296 TPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTGKTMSTPV 360
            |||||||:..|||.||||||||||||||.||||:||:||.||||||||..:.|:||.||.:.|||
Mouse   271 TPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPV 335

  Fly   361 GSLQTGHEVIISPNKDRHN-----VTAKTNAKGGVAAWPDVPKPGATLGNLTPADRH-GSVQVVS 419
            |::|  .:..:|.|::.|.     ..:|..:....|||.........|.....|||| |||||||
Mouse   336 GAVQ--QDPALSSNREAHQHRDKIQQSKNQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVS 398

  Fly   420 STNGELNPDDPTAGHSNTPITQQPEVEVVDETK--------CCCFFKRKKKKSTRQ 467
            |||||||.||||||.||.|||...||||:|||.        |||||||:|:|:.::
Mouse   399 STNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTIQR 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	236/292 (81%)
		S_TKc	62..335	CDD:214567	223/272 (82%)
		CK1gamma_C	354..428	CDD:289378	32/79 (41%)
Csnk1g3	XP_006526293.1	STKc_CK1_gamma	42..329	CDD:271028	236/292 (81%)
Csnk1g3	XP_006526293.1	CK1gamma_C	329..418	CDD:403712	40/90 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I937
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121650
Inparanoid	1	1.050	593	1.000	Inparanoid score	I970
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52120
OrthoDB	1	1.010	-	-		D281034at33208
OrthoFinder	1	1.000	-	-		FOG0001189
OrthoInspector	1	1.000	-	-		otm44193
orthoMCL	1	0.900	-	-		OOG6_101750
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R203
SonicParanoid	1	1.000	-	-		X651
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870