Protein Alignment gish and Vrk2

DIOPT Version :9

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_081536.2
• Gene: Vrk2 / 69922
• MGIID: 1917172
• Length: 503
• Species: Mus musculus
• Alignment Length: 521
• Identity: 131/521 - (25%)
• Similarity: 193/521 - (37%)
• Gaps: 137/521 - (26%)

  Fly    57 MVGPNFRVGKKIGCGNFGELRLG--KNLYNNE--HVAIKMEPMKSKAPQLHLEYRFYKLLGSH-- 115
            |.|..:.:||.||.|.||.:.|.  .|..|.:  || ||:| .:...| |..|.:||:.....
Mouse    24 MEGNRWALGKMIGSGGFGLIYLAFPTNKPNKDARHV-IKLE-YQENGP-LFSELKFYQRAAKREC 85

  Fly   116 -----ADNAPD--GIPRIYHLGTC---GGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQ 170
                 .....|  |||..|..|..   |..|..||:|.||:.|:.|.:... .|...|||.:..:
Mouse    86 IQKWIQQRKLDYLGIPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLDQNG-GFKKLTVLQLGIR 149

  Fly   171 LLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYRE--HKS 233
            :|..:||:|....::.|:|..|.|:..|:..|   :::.|:||:..|  .....|..|:|  .|.
Mouse   150 MLDVLEYIHENEYVHGDIKAANLLLDFTNPDR---VYLADYGLSYRY--CPNGNHKQYQEDPRKG 209

  Fly   234 LTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI 298
            ..||..:.|::.|.|...|||.|:|.||:..:::|.|.|||:.           |:.|     |:
Mouse   210 HNGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEA-----------KLDD-----PV 258

  Fly   299 EV------LCDGHPE-------------EFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYT 344
            .|      |.|..||             |...||.||..|.:.:.|||..|:::.         .
Mouse   259 AVQTAKTNLLDELPESVLKWAPSGSSCSELVKYLMYVHNLAYDDKPDYQKLKKIL---------N 314

  Fly   345 DEGEFDWTGKTMSTPVGSLQTGHEVIISPNKDRHNVTAKTNAKGGVAAWPDVPKPGATLGNLTPA 409
            .:|          .|:|.|:...:|        .:|..:|.|:..|    |.||......|..||
Mouse   315 PDG----------VPLGPLEFSTKV--------QSVHVRTPAQQKV----DSPKATRKPANEFPA 357

  Fly   410 DRHGSVQVVSSTNGELNPDDPTAGHSNTPITQQPEVEVVDETKCCCFFKRKKKKSTRQKXLDGVQ 474
                              ..|...|..|...|                 |::::.::...|....
Mouse   358 ------------------KFPKKVHRETRARQ-----------------REEQEDSQPTMLQSRP 387

  Fly   475 CSPEREAVTLLRATSHSNSR-DSVLNNPSQDYIQ--------QATSQHTLRYPPSASMLTPTPTT 530
            .:||......:...|...|. .|:...||....|        ..|.:..:|.|.|......|||.
Mouse   388 AAPENSRTRKIHEYSDIFSEMQSLQQTPSYMSFQGSYCKPYLDCTRRDPIRKPRSLPRYRHTPTG 452

  Fly   531 N 531
            |
Mouse   453 N 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	93/329 (28%)
		S_TKc	62..335	CDD:214567	92/309 (30%)
		CK1gamma_C	354..428	CDD:289378	14/73 (19%)
Vrk2	NP_081536.2	PKc_like	16..314	CDD:389743	94/323 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..353		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..395		7/49 (14%)
		Interaction with MAP3K7. /evidence=ECO:0000250	392..503		14/62 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810