DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and Csnk1g3

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_074046.1	Gene:	Csnk1g3 / 64823	RGDID:	621408	Length:	448	Species:	Rattus norvegicus

Alignment Length:	438	Identity:	309/438 - (70%)
Similarity:	356/438 - (81%)	Gaps:	14/438 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KSSSNNMYSTRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAP 100
            :.|..:.:|||.:.|:::||||||||||||||||||||||||||||||.||:||||:|||||:||
  Rat    17 RPSGRSGHSTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAP 81

  Fly   101 QLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVL 165
            ||||||||||.|||     .||||::|:.|.| |:||||||||||.||||||::|.|.|||||||
  Rat    82 QLHLEYRFYKQLGS-----GDGIPQVYYFGPC-GKYNAMVLELLGPSLEDLFDLCDRTFSLKTVL 140

  Fly   166 MIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYRE 230
            |||.||:.|:|||||::|||||||||||||||...|.:::||||||||||||||.:|.:||||||
  Rat   141 MIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKAQQVIHIIDFGLAKEYIDPETKKHIPYRE 205

  Fly   231 HKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRA 295
            ||||||||||||||||:|:||||||||||||||||||||||||||||||||||||||||||||||
  Rat   206 HKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRA 270

  Fly   296 TPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTGKTMSTPV 360
            |||||||:..|||.||||||||||||||.||||:||:||.||||||||..:.|:||.||.:.|||
  Rat   271 TPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPV 335

  Fly   361 GSLQTGHEVIISPNKDRHN-----VTAKTNAKGGVAAWPDVPKPGATLGNLTPADRH-GSVQVVS 419
            |::|  .:..:|.|::.|.     ..:|..:....|||.........|.....|||| |||||||
  Rat   336 GAVQ--QDPALSSNREAHQHRDKIQQSKNQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVS 398

  Fly   420 STNGELNPDDPTAGHSNTPITQQPEVEVVDETKCCCFFKRKKKKSTRQ 467
            |||||||.||||||.||.|||...||||:|||||||||||:|:|:.::
  Rat   399 STNGELNTDDPTAGRSNAPITAPTEVEVMDETKCCCFFKRRKRKTIQR 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	236/292 (81%)
		S_TKc	62..335	CDD:214567	223/272 (82%)
		CK1gamma_C	354..428	CDD:289378	32/79 (41%)
Csnk1g3	NP_074046.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		5/17 (29%)
		STKc_CK1_gamma	42..329	CDD:271028	236/292 (81%)
		CK1gamma_C	329..418	CDD:403712	40/90 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..375		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..417		22/24 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I909
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121650
Inparanoid	1	1.050	613	1.000	Inparanoid score	I873
OMA	1	1.010	-	-		QHG52120
OrthoDB	1	1.010	-	-		D281034at33208
OrthoFinder	1	1.000	-	-		FOG0001189
OrthoInspector	1	1.000	-	-		otm46286
orthoMCL	1	0.900	-	-		OOG6_101750
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X651
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840