DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gish and csnk1g2a

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_005171263.1	Gene:	csnk1g2a / 554152	ZFINID:	ZDB-GENE-030131-6445	Length:	452	Species:	Danio rerio

Alignment Length:	471	Identity:	306/471 - (64%)
Similarity:	358/471 - (76%)	Gaps:	32/471 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ERQASGGGPQTTTAGPSAGNVANATTALAGGKSSSNNMYSTRQSVSTTTGVLMVGPNFRVGKKIG 69
            :::..|||......|........:.|...|.:.|.||           |||||||||||||||||
Zfish     4 DKRGGGGGKGEAEDGKRMSKTGGSRTGHGGSRGSGNN-----------TGVLMVGPNFRVGKKIG 57

  Fly    70 CGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCGG 134
            ||||||||||||||.||:||||:||:||:||||||||||||.||    || :|:|::|:.|.| |
Zfish    58 CGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLG----NA-EGVPQVYYFGPC-G 116

  Fly   135 RYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTS 199
            :||||||||||.||||||::|.|.||||||||||.||:.|:|:||:|.||||||||||||:||..
Zfish   117 KYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLITRMEFVHTRSLIYRDVKPENFLVGRPG 181

  Fly   200 TKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMF 264
            |||:..||||||||||||||.:|.:||||||||||||||||||||||:|:|||||||||||||||
Zfish   182 TKRQHTIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMF 246

  Fly   265 MYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDF 329
            ||||||||||||||||||||||||||||||||||||||:..| |.||||||||||||||.|||::
Zfish   247 MYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCESFP-EMATYLRYVRRLDFFERPDYEY 310

  Fly   330 LRRLFQDLFDRKGYTDEGEFDWTGKTMSTPVGSLQTGHEVIISP-NKDRHNVTAKTNA---KGGV 390
            ||:||.|||||.||..:.|:||.||.:.||:|.:.:  :..:.| |:|:.....|..:   ||..
Zfish   311 LRKLFTDLFDRNGYVFDYEYDWVGKPLPTPIGPMPS--DTPLQPSNRDKAQPQTKNQSPEPKGSE 373

  Fly   391 AAWPDVPKPGAT---LGNLTPADR-HGSVQVVSSTNGELNPDDPTAGHSNTPITQQPEVEVVDET 451
            :.    |.|...   ||:...||| .|||||:||||||:|.|||||||||.|||...||||.|:|
Zfish   374 SQ----PTPVTNRELLGSHLTADRLGGSVQVMSSTNGEVNTDDPTAGHSNAPITAPAEVEVADDT 434

  Fly   452 KCCCFFKRKKKKSTRQ 467
            ||||||||:|:|:.::
Zfish   435 KCCCFFKRRKRKALQR 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	231/292 (79%)
		S_TKc	62..335	CDD:214567	219/272 (81%)
		CK1gamma_C	354..428	CDD:289378	29/81 (36%)
csnk1g2a	XP_005171263.1	SPS1	49..415	CDD:223589	264/378 (70%)
		STKc_CK1_gamma	49..335	CDD:271028	231/292 (79%)
		CK1gamma_C	335..411	CDD:289378	29/81 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593622
Domainoid	1	1.000	361	1.000	Domainoid score	I910
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	579	1.000	Inparanoid score	I993
OMA	1	1.010	-	-		QHG52120
OrthoDB	1	1.010	-	-		D281034at33208
OrthoFinder	1	1.000	-	-		FOG0001189
OrthoInspector	1	1.000	-	-		otm26573
orthoMCL	1	0.900	-	-		OOG6_101750
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R203
SonicParanoid	1	1.000	-	-		X651
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800