DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and CSNK1G1

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001316534.1	Gene:	CSNK1G1 / 53944	HGNCID:	2454	Length:	475	Species:	Homo sapiens

Alignment Length:	473	Identity:	302/473 - (63%)
Similarity:	345/473 - (72%)	Gaps:	47/473 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QRRERQASGGGPQTTTAGPSAGNVANATTALAGGKSSSNNMYSTRQSVSTTTGVLMVGPNFRVGK 66
            ::.|||        .|..|.|...|:.:.  ..|.|||             :|||||||||||||
Human     7 EKDERQ--------RTTKPMAQRSAHCSR--PSGSSSS-------------SGVLMVGPNFRVGK 48

  Fly    67 KIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPRIYHLGT 131
            |||||||||||||||||.||:||||:||:||:||||||||||||.|||    |.:|:|::|:.|.
Human    49 KIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGS----AGEGLPQVYYFGP 109

  Fly   132 CGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIG 196
            | |:||||||||||.||||||::|.|.|:||||||||.|||.|:|||||::||||||||||||||
Human   110 C-GKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIG 173

  Fly   197 RTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALG 261
            |...|:|.:||||||||||||||.:|.:||||||||||||||||||||||:|:||||||||||||
Human   174 RQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALG 238

  Fly   262 HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPD 326
            |||||||||||||||||||||||||||||||||.||||.||:..|||.||||||||||||||.||
Human   239 HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPD 303

  Fly   327 YDFLRRLFQDLFDRKGYTDEGEFDWTGKTMSTPVGS--LQTGHEVII---SPNKDR-------HN 379
            |::||.||.|||::||||.:..:||.|:.:.|||||  :.:|...|.   ..::||       .|
Human   304 YEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRPSQQQPLRN 368

  Fly   380 VTAKTNAKGGVAAWPDVPKPGATLGNLT---PADRH-GSVQVVSSTNGELNPDDPTAGHSNTPIT 440
            ....:..:|   .|...|........||   .|||| ||||||||||||||.||||..|||.|||
Human   369 QNVSSERRG---EWEIQPSRQTNTSYLTSHLAADRHGGSVQVVSSTNGELNVDDPTGAHSNAPIT 430

  Fly   441 QQPEVEVVDETKCCCFFK 458
            ...|||||:|.||..|.|
Human   431 AHAEVEVVEEAKCIMFHK 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	230/292 (79%)
		S_TKc	62..335	CDD:214567	219/272 (81%)
		CK1gamma_C	354..428	CDD:289378	33/89 (37%)
CSNK1G1	NP_001316534.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I937
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	605	1.000	Inparanoid score	I940
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52120
OrthoDB	1	1.010	-	-		D281034at33208
OrthoFinder	1	1.000	-	-		FOG0001189
OrthoInspector	1	1.000	-	-		otm42139
orthoMCL	1	0.900	-	-		OOG6_101750
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R203
SonicParanoid	1	1.000	-	-		X651
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870