Protein Alignment gish and CSNK1G1

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001316534.1
• Gene: CSNK1G1 / 53944
• HGNCID: 2454
• Length: 475
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 302/473 - (63%)
• Similarity: 345/473 - (72%)
• Gaps: 47/473 - (9%)

  Fly     2 QRRERQASGGGPQTTTAGPSAGNVANATTALAGGKSSSNNMYSTRQSVSTTTGVLMVGPNFRVGK 66
            ::.|||        .|..|.|...|:.:.  ..|.|||             :|||||||||||||
Human     7 EKDERQ--------RTTKPMAQRSAHCSR--PSGSSSS-------------SGVLMVGPNFRVGK 48

  Fly    67 KIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPRIYHLGT 131
            |||||||||||||||||.||:||||:||:||:||||||||||||.|||    |.:|:|::|:.|.
Human    49 KIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGS----AGEGLPQVYYFGP 109

  Fly   132 CGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIG 196
            | |:||||||||||.||||||::|.|.|:||||||||.|||.|:|||||::||||||||||||||
Human   110 C-GKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIG 173

  Fly   197 RTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALG 261
            |...|:|.:||||||||||||||.:|.:||||||||||||||||||||||:|:||||||||||||
Human   174 RQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALG 238

  Fly   262 HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPD 326
            |||||||||||||||||||||||||||||||||.||||.||:..|||.||||||||||||||.||
Human   239 HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPD 303

  Fly   327 YDFLRRLFQDLFDRKGYTDEGEFDWTGKTMSTPVGS--LQTGHEVII---SPNKDR-------HN 379
            |::||.||.|||::||||.:..:||.|:.:.|||||  :.:|...|.   ..::||       .|
Human   304 YEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRPSQQQPLRN 368

  Fly   380 VTAKTNAKGGVAAWPDVPKPGATLGNLT---PADRH-GSVQVVSSTNGELNPDDPTAGHSNTPIT 440
            ....:..:|   .|...|........||   .|||| ||||||||||||||.||||..|||.|||
Human   369 QNVSSERRG---EWEIQPSRQTNTSYLTSHLAADRHGGSVQVVSSTNGELNVDDPTGAHSNAPIT 430

  Fly   441 QQPEVEVVDETKCCCFFK 458
            ...|||||:|.||..|.|
Human   431 AHAEVEVVEEAKCIMFHK 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	230/292 (79%)
		CK1gamma_C	354..439	CDD:463640	40/100 (40%)
CSNK1G1	NP_001316534.1	STKc_CK1_gamma	43..331	CDD:271028	230/292 (79%)
		CK1gamma_C	331..429	CDD:463640	40/100 (40%)