DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and CG12147

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_649536.1	Gene:	CG12147 / 40651	FlyBaseID:	FBgn0037325	Length:	477	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	172/457 - (37%)
Similarity:	244/457 - (53%)	Gaps:	71/457 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 120
            ::|...:|:.|:||.|:||||...:.|..:|.||||:|....|.|.|..|.|.|.:|....
  Fly    62 IIVAGKYRLLKRIGNGSFGELFQAEGLKYHEKVAIKLESSTVKHPLLPREARIYGILQGGL---- 122

  Fly   121 DGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIY 185
             |||.:.|..| .|.||.||::|||.:||||.|:|:|.||:||.||:|.|:|.|:|.:|.|..|:
  Fly   123 -GIPHVKHYAT-EGAYNVMVMDLLGPTLEDLLNLCSRSFSMKTTLMLADQILARVELLHRRCFIH 185

  Fly   186 RDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGRE 250
            ||:||:|||:|  ..:.:..:::|||||||::..|.|.:||.|.|::.|.|||||.|:..|.. |
  Fly   186 RDIKPDNFLMG--LNRHQTQVYMIDFGLAKKFYSLRTQKHIGYTENRDLVGTARYASVRAHYA-E 247

  Fly   251 QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRY 315
            ||||||||::|::.:||.||.|||||::|.:..::|:||.:.|...|::.||.|.|.||..||:|
  Fly   248 QSRRDDLESVGYLLLYFQRGRLPWQGIRAQSQAQKYEKIAEYKANIPLQQLCSGLPVEFFMYLKY 312

  Fly   316 VRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTG-KTMSTPVGSLQTGHE--------VII 371
            .|:|.|.|.|||.:|::||:.||..:....:..|||.. |..|....|.|.|.|        |::
  Fly   313 CRKLHFAEKPDYVYLQQLFKVLFRNQYKVCDFLFDWVVLKRESPEQQSQQKGRERDRGGKRNVVV 377

  Fly   372 SP----NKDRHNVTAKTNAKGGVAAWPDVPKPGATLGNLTPADRHGSVQVVSSTNGE-LNPDDPT 431
            ..    ||||.:.|.:...|.|              |:|...:.:      .||.|| .|.|.|.
  Fly   378 QKERHRNKDRDSDTQRCRIKNG--------------GDLLEIEEN------ESTTGEDPNEDKPQ 422

  Fly   432 AGHSNTPITQQPEVEVVDETKCCCFFKRKKKK----------STRQKXLDGVQCSPEREAVTLLR 486
            ..|...               |.|.:..:||:          .|.::.|.|.|   |:|....||
  Fly   423 KKHGKA---------------CSCSYHLQKKRLQDRDRRAPLMTERRILSGEQ---EQELELELR 469

  Fly   487 AT 488
            .:
  Fly   470 GS 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	135/293 (46%)
		S_TKc	62..335	CDD:214567	129/272 (47%)
		CK1gamma_C	354..428	CDD:289378	21/86 (24%)
CG12147	NP_649536.1	STKc_CK1	67..331	CDD:270918	128/272 (47%)
CG12147	NP_649536.1	SPS1	67..>306	CDD:223589	115/247 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452704
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840