DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gish and CG5790

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001286037.1	Gene:	CG5790 / 35095	FlyBaseID:	FBgn0032677	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	673	Identity:	130/673 - (19%)
Similarity:	206/673 - (30%)	Gaps:	278/673 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GPSAGNVANATTAL-AGGKSSS-----NNMYS---------TRQSVSTTTG-------VLMVGPN 61
            |.||.|:..|.|.| :.|||||     |..|:         |..|||.|..       :|...|.
  Fly    28 GKSATNMDCANTNLESAGKSSSTNYNRNRFYNERFVPMASGTMPSVSGTNHHSRHQQLLLQQAPK 92

  Fly    62 ----------------------------------------------------FRVGKKIGCGNFG 74
                                                                |.|..:||.|.|.
  Fly    93 CTADLNEKLVKINRQNANKELSTIQAKDMQSVDKNEEALKELQESIPEINKIFDVHCRIGSGTFS 157

  Fly    75 ELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPR----IYHLG----- 130
            .:.||              .::.:...:..:.|.:.:...:..|.|:.|.|    :|.:|
  Fly   158 TVLLG--------------TLQRERGLVETQRRRFAIKHHNPTNHPERILRELECMYRIGGVENV 208

  Fly   131 ---TCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPEN 192
               .|..|||..|..::.....|.|:...|..:...:....:.||..:.:||..::|:|||||.|
  Fly   209 IGINCCIRYNDNVAFIMPYMTHDRFHDIYRSLNFPEIRDYLRNLLIALRHVHKFNVIHRDVKPSN 273

  Fly   193 FLIGRTSTKREKIIHIIDFGLAKEYI---------------------DLDTNRHIPYREHKSLT- 235
            .|..|.:.|    ..:.|||||:...                     ||:..|.:      :||
  Fly   274 ILYNRRTGK----FLLCDFGLAQRIADDGSVVQSSDLSSREVFSILRDLENGRSV------TLTD 328

  Fly   236 GTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 300
            |.:.......:|.|.:.|     |||.      .||:.    :|.|.....||:.:.
  Fly   329 GNSAQAEAEDYMARRRMR-----ALGG------GGSVE----RAVTGPPSIQKLREQ-------- 370

  Fly   301 LCDGH------PEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTGKTMSTP 359
             ..||      ..:.|..:|.:.||.
  Fly   371 -AGGHLTKKDVANQRADTMRLLNRLR--------------------------------------- 395

  Fly   360 VGSLQTGHEVIISPNKDRHNVTAKTN--------AKGGVAAW--PDV----PKPG---------- 400
                      ::|||.|.:|....||        ::.|...:  |:|    ||..
  Fly   396 ----------LVSPNADPNNYVVSTNTSKKEMHASRAGTPGYRPPEVLLRYPKQSTAVDVWAAGV 450

  Fly   401 ---ATLGNLTPADR--H--GSVQVVSSTNGELNPDDPTAGHSNTPITQQPEVEVVDETKCCCFFK 458
               :.|..|.|..:  |  |::..:.:..|:: |...||...:..|....:|..:|..:.|..|:
  Fly   451 IMLSLLSGLHPFFKAPHDCGALAEIINLFGDM-PVRKTAFLLDRLILLAQKVNTLDLRRVCMRFR 514

  Fly   459 RK--------KKKSTRQKXLDGV--QC-SPEREAVTLLRATS-HSNSRDSVLN------------ 499
            ..        ::|..|.   ||.  .| |.|:.....|.:.| |:..|...|:
  Fly   515 HADFFLAPEIQRKYQRP---DGTTEMCRSCEQPTFNCLCSNSGHNLERYDGLDIFPAVAYDLLSR 576

  Fly   500 ----NPSQDYIQQATSQHTLRYP 518
                ||.    ::.|::..|::|
  Fly   577 LLEVNPQ----KRITAEEALKHP 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	66/384 (17%)
		S_TKc	62..335	CDD:214567	66/312 (21%)
		CK1gamma_C	354..428	CDD:289378	18/104 (17%)
CG5790	NP_001286037.1	STKc_Cdc7	143..597	CDD:270921	109/558 (20%)
		S_TKc	145..597	CDD:214567	109/556 (20%)
		PKc_like	<238..>363	CDD:304357	36/149 (24%)
		PKc_like	<364..>462	CDD:304357	22/155 (14%)
		PKc_like	<427..597	CDD:304357	35/177 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452708
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11909
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030