Protein Alignment gish and cki3

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_593916.1
• Gene: cki3 / 2542395
• PomBaseID: SPAC1805.05
• Length: 439
• Species: Schizosaccharomyces pombe
• Alignment Length: 495
• Identity: 211/495 - (42%)
• Similarity: 273/495 - (55%)
• Gaps: 95/495 - (19%)

  Fly    44 STRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRF 108
            ||..|.|...||     ::|||||||.|:||.|..|.||.||:.:|:|.|..||:.|||..||..
pombe     2 STTSSHSNVVGV-----HYRVGKKIGEGSFGMLFQGVNLINNQPIALKFESRKSEVPQLRDEYLT 61

  Fly   109 YKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLH 173
            ||||     ....|||.:|:.|. .|.||.:|::|||.||||||:.|.|:||.|||.|||||::.
pombe    62 YKLL-----MGLPGIPSVYYYGQ-EGMYNLLVMDLLGPSLEDLFDYCGRRFSPKTVAMIAKQMIT 120

  Fly   174 RIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTA 238
            ||:.||.||.||||:||:|||||...:|.|.:|:.:|||:||:|.|..|:.|.||.|||||:|||
pombe   121 RIQSVHERHFIYRDIKPDNFLIGFPGSKTENVIYAVDFGMAKQYRDPKTHVHRPYNEHKSLSGTA 185

  Fly   239 RYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCD 303
            ||||||||:|||||||||||::||:||||||||||||||||.|.|::|:|||:.|:.||::.||:
pombe   186 RYMSINTHLGREQSRRDDLESMGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQVTPLKELCE 250

  Fly   304 GHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWT----GKTMSTPVGSLQ 364
            |:|:||..|:.|.|.|.:.|.||||:||.||..|..|...||:|::|||    ||....   |..
pombe   251 GYPKEFLQYMIYARNLGYEEAPDYDYLRSLFDSLLLRINETDDGKYDWTLLNNGKGWQY---SAA 312

  Fly   365 TGHEVIISPNKDRHNVTAKTNAKGGVAAWPDVPKPGATLGNLTPADRHGSVQVVSSTNGELNPDD 429
            ..|.|     :.||  |..||.:                       |..::...:.|...|
pombe   313 KQHVV-----QRRH--TQGTNNR-----------------------RQSTIPPYARTRQNL---- 343

  Fly   430 PTAGHSNTPITQQPEVEVVDETKCCCFFKRKKKKSTRQKXLDGVQCSPEREAVTLLRATSHSNSR 494
                 .::|..|.|...|||.:           .:|::. :.|...||:.:.
pombe   344 -----LSSPSKQTPVNNVVDAS-----------VATQKDGIPGKAASPQVQQ------------- 379

  Fly   495 DSVLNNPSQDYIQQATSQHTLRYPPSASMLTPTPTTNTPT 534
                        ||.||....:.|.....  |.|.|..||
pombe   380 ------------QQQTSSAQQQQPQRVEQ--PAPQTTQPT 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	172/296 (58%)
		CK1gamma_C	354..439	CDD:463640	12/84 (14%)
cki3	NP_593916.1	Protein Kinases, catalytic domain	14..290	CDD:473864	166/281 (59%)