DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and ZK666.8

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_496261.2	Gene:	ZK666.8 / 191385	WormBaseID:	WBGene00014048	Length:	391	Species:	Caenorhabditis elegans

Alignment Length:	315	Identity:	93/315 - (29%)
Similarity:	149/315 - (47%)	Gaps:	34/315 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TTTGVLMVGPNFR----VGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSK---APQLHLEYR- 107
            |:|.::.:...||    :...||.|.:||:.|..::...|.||||.||:..|   |.::.||..
Worm    78 TSTPLMPIDEKFRKRWHIEGIIGKGGYGEIYLAIDMKLAEEVAIKAEPLVRKGKIARRMILEQAV 142

  Fly   108 FYKLLGS-HADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNIC-ARKFSLKTVLMIAKQ 170
            ..||.|. |       :|.|:..|.. ..:|.:||:||..:|.|:..:. .||.|..:|..||.|
Worm   143 LVKLQGKPH-------VPWIFGSGHT-ENFNFIVLQLLSANLGDIRRMSPTRKLSKSSVGRIAVQ 199

  Fly   171 LLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHK--- 232
            .:..:..:|....::||:||.|...|.|| |...::.::||||.:.|.|.|..    :|.|:
Worm   200 AIAALRDLHDVGYLHRDIKPGNMCFGITS-KTRHVLMLLDFGLVRRYKDPDGE----WRTHRVKA 259

  Fly   233 SLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRAT 296
            ...||.||:|...|...||:..||:.:|.:..:..|.|.|||:.:: :|.:    .|:.|.....
Worm   260 GFRGTQRYVSTRVHRRLEQTPTDDMVSLLYTLIELLAGELPWRNIENSDAI----WKMKDELHHG 320

  Fly   297 PIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDW 351
            .|:...:. .:|...:.:.|.|||......|..|:...:.|:..|..:|  .:||
Worm   321 QIDHFHES-SQELIEFSQLVSRLDPMSELPYTTLQASVKKLYLPKKLSD--PYDW 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	91/305 (30%)
		S_TKc	62..335	CDD:214567	86/286 (30%)
		CK1gamma_C	354..428	CDD:289378
ZK666.8	NP_496261.2	PKc_like	92..354	CDD:389743	83/279 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810