Protein Alignment gish and W06F12.3

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_499835.1
• Gene: W06F12.3 / 189253
• WormBaseID: WBGene00012307
• Length: 318
• Species: Caenorhabditis elegans
• Alignment Length: 300
• Identity: 84/300 - (28%)
• Similarity: 144/300 - (48%)
• Gaps: 37/300 - (12%)

  Fly    62 FRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPRI 126
            |:|.|.:|.|.||::....::.....||:|:||...::.::.||......| :|:.:    ||::
 Worm    38 FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVEL-AHSPH----IPKV 97

  Fly   127 YHLGTCGGRYNAMVLELLGLSLEDLFNI-CARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKP 190
            ::.|..|| ||.:|::|||.::.||... ..|.||.:|...:..|.|..::.:|....|:||:||
 Worm    98 HYSGEIGG-YNFIVMQLLGSNITDLRKFQKGRCFSAETTARVGIQCLEGLKQIHELGYIHRDIKP 161

  Fly   191 ENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRD 255
            .|..:|....||  :::|:|||:|:: |...:....|.|.:.|..||.||:|:..|..:||...|
 Worm   162 SNICVGIGEHKR--VLYIVDFGMARQ-IRFPSGAFRPERPYASFRGTTRYVSLAAHERKEQGFAD 223

  Fly   256 DLEALGHMFMYFLRGSLPWQGL--------KADTLKERYQ--KIGDTKRATPIEVLCDGHPEEFA 310
            |:..|....:....| |||:.:        ....|...:|  |:|                :.|.
 Worm   224 DIWCLFFSLLELAEG-LPWKNVVDQDQVYHAKQLLLRNFQSRKMG----------------QNFG 271

  Fly   311 TYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFD 350
            |:.|.:..:...|||:|:....:.:....|....:|.|:|
 Worm   272 TFPRALELIKRTETPNYENFIVILKSCSSRVNEWEEFEWD 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	83/299 (28%)
		CK1gamma_C	354..439	CDD:463640
W06F12.3	NP_499835.1	Protein Kinases, catalytic domain	38..289	CDD:473864	79/276 (29%)