Protein Alignment gish and W03G9.5

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_491490.1
• Gene: W03G9.5 / 189171
• WormBaseID: WBGene00021016
• Length: 488
• Species: Caenorhabditis elegans
• Alignment Length: 509
• Identity: 125/509 - (24%)
• Similarity: 209/509 - (41%)
• Gaps: 146/509 - (28%)

  Fly    69 GCGNFGELRLGKNLYNNEHVAIKME-PMKSKAPQLHLEYRFYKLLG-------------SHADNA 119
            |||...|:.:.|  ......|.|.| .:..:.|.|.:|::....|.             ..:||
 Worm    28 GCGVIYEVAMVK--CPGRRFACKAETTVFDEDPTLPMEHKIISKLNEKNSIHCVELIDKGQSDN- 89

  Fly   120 PDGIPRIYHLGTCGGRYNAMVLELLGLSLEDL-FNICARKFSLKTVLMIAKQLLHRIEYVHSRHL 183
                            |..:|:.|||.||:.: ..:...|||..:.|::..|.|..|:.:|....
 Worm    90 ----------------YQFIVMTLLGPSLDAIRATLPTNKFSTFSTLVMGIQALDSIKEIHDIGF 138

  Fly   184 IYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLD----------TNRHIPYREHKSLTGTA 238
            ::|||||.||.||...|.:::::|::|||::::|:..|          ..|.:|:|      ||.
 Worm   139 VHRDVKPANFAIGALGTPKQRLVHVLDFGISRQYLVKDGENGGLRIRKPRRIVPFR------GTL 197

  Fly   239 RYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGL----KADTLKERYQKIGDTKRATPIE 299
            ||.|:.....:||.|.|||.:|.:|.:.|::|||||.|:    |...:||            .:.
 Worm   198 RYCSVAAQERKEQGRHDDLWSLFYMIVEFVKGSLPWTGIMEEEKVIVMKE------------DVT 250

  Fly   300 VLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDW----------TGK 354
            .|.:|...|.|.:.:::..|.:...|||..||.|..::|.|:.:..:.:.||          ..|
 Worm   251 ELFNGLESECAMFAQHLSVLRYQTNPDYALLRDLLMNIFVRRNFNAQMKVDWEKGGRYESHFEKK 315

  Fly   355 TMSTPVGSLQTGHEVIIS-----PNKDRHNVT-------AKTNAKGGVAAWPDVPKPGATLGNLT 407
            |.:.||...:...||.:|     |..:| |:|       .||..:.|:              |..
 Worm   316 TSTLPVVIEKDMTEVDLSKLLNVPQNER-NITMEEIIAAGKTTEEEGL--------------NTA 365

  Fly   408 PADRHGSVQVVSSTNG-----ELNPDDPTAGHSNTP-------ITQQP---EVEVVDETKCCCFF 457
            ..|     .:|...||     |..|..|:| .|.|.       |.:.|   ::|.:::.     :
 Worm   366 QDD-----TIVEDENGFLGKQEAKPATPSA-RSETSKKVKRRYIARTPSAHKIEQIEKN-----W 419

  Fly   458 KRKKKKSTRQKXLDGVQCS---------PE--------REAVTLLRATSHSNSR 494
            |:|::::.::| |...:.:         ||        .|:..|..|.|..::|
 Worm   420 KKKEEEANKEKLLKNARAARRAKEDFIVPEDNTVQKRKLESTQLSSAVSTKSTR 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	86/323 (27%)
		CK1gamma_C	354..439	CDD:463640	25/108 (23%)
W03G9.5	NP_491490.1	Protein Kinases, catalytic domain	22..285	CDD:473864	81/293 (28%)