Protein Alignment gish and M7.7

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_502068.2
• Gene: M7.7 / 187456
• WormBaseID: WBGene00010883
• Length: 370
• Species: Caenorhabditis elegans
• Alignment Length: 317
• Identity: 82/317 - (25%)
• Similarity: 144/317 - (45%)
• Gaps: 49/317 - (15%)

  Fly    62 FRVGKKIGCGNFGELRLGKNLY--NNEHVAIKMEPMKSKAPQLHLEYRFYKLLGS--HADNAPDG 122
            |.:.|.:..|.||:: ...::|  :||...:|:|...:....|:.|....|.|.:  :.:|.|..
 Worm    26 FVLQKMLSGGGFGQI-FEASIYGSSNEKSVVKVEGQNAMFQLLYNECSCLKSLNTAFNPNNLPGA 89

  Fly   123 IP--RIYHLGTCGGRYNAMVLELLGLSLEDLFNICARK------FSLKTVLMIAKQLLHRIEYVH 179
            .|  |.:..|...| :..:.:|..|.:|.||     ||      ||:.|.|.|..:.:..::.:|
 Worm    90 SPFLRFHGYGGIDG-FRWLAMERCGENLSDL-----RKDTPLGRFSVTTSLFIFYKFIEALQMMH 148

  Fly   180 SRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLD-----TNRHIPYREHKSLTGTAR 239
            |...::|||||.|..:   ..|..:.::::|||::|.|::.|     .....|:|      ||.|
 Worm   149 SIGWLHRDVKPANVCV---DLKSRRHLYLLDFGMSKIYVEKDGTLKARRTSAPFR------GTLR 204

  Fly   240 YMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDG 304
            |:|:|.|..::.||.||:.:..::....:.|.|||:.: .|.:|...:|:     ::.:..|..|
 Worm   205 YVSVNIHRRQDASRWDDIWSAFYIATENMVGHLPWRRM-GDAMKVEEKKV-----SSDLSRLIYG 263

  Fly   305 HPEEFATYLRYVR------RLD---FFETPDYD-FLRRLFQDLFDRKGYTDEGEFDW 351
            ........:.|:.      :.|   |:..|.|| .|:::..||..|....|....||
 Worm   264 SDRSRPKCMEYIENELNNSQSDPSYFYVPPAYDKMLQQIAGDLRLRNLSMDTVCLDW 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	82/317 (26%)
		CK1gamma_C	354..439	CDD:463640
M7.7	NP_502068.2	Protein Kinases, catalytic domain	25..300	CDD:473864	75/295 (25%)