Protein Alignment gish and K09C6.2

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_503344.2
• Gene: K09C6.2 / 187199
• WormBaseID: WBGene00019556
• Length: 634
• Species: Caenorhabditis elegans
• Alignment Length: 500
• Identity: 85/500 - (17%)
• Similarity: 180/500 - (36%)
• Gaps: 101/500 - (20%)

  Fly    37 SSSNNMYSTRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSK--- 98
            ||::|.:...||:                 :.||....:|...|   |.||:.::.:..|.:
 Worm    26 SSTSNQFWLVQSI-----------------RSGCMRSAKLASQK---NPEHLQLQKDLNKQRKLL 70

  Fly    99 ---APQLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFS 160
               .|:|               :.|..|.|:..:| ....:..::.|..|:....||:......:
 Worm    71 FDLLPEL---------------SNPSHIARLVDVG-YDDDFKFLIFEDFGMDFLTLFDEFGPVLN 119

  Fly   161 LKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRH 225
            ..|:.:|:....:.|:.:||..:::.|::|.:|.:.:         |..:..:.      |.:|.
 Worm   120 PATLFLISYFTFNAIKELHSFDIVHLDIRPSSFSVNQ---------HPFNIKIT------DYSRC 169

  Fly   226 IPYREHKSLTGTARYMSINTHMGREQSRR----DDLEALGHMFMYFLR-GSLPWQGLKADTLKER 285
            :..:....:...||..|.:..:..::..:    .|.||..:..::... ..|||.|...:.|:.:
 Worm   170 MTRKPEMKVPDDARPDSFSPRVFHQKDAQFDEFVDFEAWVYTMLFLCTVEKLPWFGDAENMLRLK 234

  Fly   286 YQKIGDTKRATPIEVLCDG-----------HPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFD 339
            .:...|     |:..|.||           ..::..||..::..::...:.|.    ..:.|...
 Worm   235 EEFFND-----PLNYLYDGCADFVPLVACFIADKKLTYDTFMEEMNLIFSVDV----MQYSDKEQ 290

  Fly   340 RKGYTDEGEFDWTGKTMSTPVGSLQTGHEVII-------SPNKDRHNV--TAKTNAKGGVAAWPD 395
            .:.||.: |.:...||...|  ...|.:.:.|       :.:.|..|:  :.:.|.:........
 Worm   291 PRLYTMK-ELEEVKKTRRAP--DFYTNNAIDIAESHWHAADDSDHDNLRTSDEENEQKSETKKDS 352

  Fly   396 VPKPGATLGNLTPADRHGSVQVVSSTNGELNPDD--PTAGHSNTPITQQPEVEVVDE--TKCCCF 456
            ..:..|.:.:.| ......:...||::|...|.:  .:|.....|..:.|..|..|:  |:....
 Worm   353 CERSSAEVSSST-EQTSAPMSEASSSDGRKKPKNAGKSAERKGKPAEKNPSSEKDDDGATEPMSG 416

  Fly   457 FKRKKKKSTRQKXLDGVQCSPEREAVTLLRATSHSNSRDSVLNNP 501
            .:|:...|........|:..||::...  |..:.:..::|.::.|
 Worm   417 VERRSTPSDVVNEKGRVKGDPEKQKQD--RKENKTEEQNSKISAP 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	52/314 (17%)
		CK1gamma_C	354..439	CDD:463640	15/95 (16%)
K09C6.2	NP_503344.2	Protein Kinases, catalytic domain	57..>173	CDD:473864	22/146 (15%)
		Protein Kinases, catalytic domain	<134..253	CDD:473864	25/138 (18%)
		PTZ00121	<270..>455	CDD:173412	31/194 (16%)