Protein Alignment gish and F22F1.2

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_509374.1
• Gene: F22F1.2 / 184850
• WormBaseID: WBGene00017714
• Length: 299
• Species: Caenorhabditis elegans
• Alignment Length: 312
• Identity: 71/312 - (22%)
• Similarity: 131/312 - (41%)
• Gaps: 72/312 - (23%)

  Fly    61 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYK---------LLGSHA 116
            |:.:.||:|.|::|::...::..||:...||:         :|.|....:         .|.:.|
 Worm    10 NYILEKKLGEGSYGDVYFCRDERNNKWSVIKL---------IHKEINGVRDETWRRETFALTALA 65

  Fly   117 DNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARK----FSLKTVLMIAKQLLHRIEY 177
            :  ..||.|:|..|.. ..:|.:|:|.|   |:||.||..|.    ||..|...|..||:..::.
 Worm    66 E--VRGISRMYDYGAT-DIHNYIVMEPL---LDDLTNIARRNGIKGFSKSTGFHILWQLVKILQD 124

  Fly   178 VHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNR--------------HIPY 228
            |||..:.:.|:|.:|.:|  :.:.:..::.::||||::.:.|.:.||              |.|.
 Worm   125 VHSFGIAHGDIKADNLMI--SGSNKTFMLSLVDFGLSRSFKDHNGNRTPPIPFPSGCINLIHTPA 187

  Fly   229 REHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQ---GLKADTLKERYQKIG 290
            |               |..|:.....:||..:.:: ....|...||:   |.|...||:.:.:
 Worm   188 R---------------TANGKPHMEAEDLMQVAYL-ACICRKLAPWEDIDGHKMTKLKKAFAE-- 234

  Fly   291 DTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKG 342
                 .|.:.|  |..::....::.:.:....:.|:|..:..|.|::....|
 Worm   235 -----KPKKFL--GEHQDLKPIIKIIAKQKHGKEPNYKEIMDLLQEMLTSSG 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	71/312 (23%)
		CK1gamma_C	354..439	CDD:463640
F22F1.2	NP_509374.1	Protein Kinases, catalytic domain	15..272	CDD:473864	68/298 (23%)