Protein Alignment gish and ttbk-6

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_498080.1
• Gene: ttbk-6 / 183478
• WormBaseID: WBGene00016673
• Length: 290
• Species: Caenorhabditis elegans
• Alignment Length: 261
• Identity: 78/261 - (29%)
• Similarity: 127/261 - (48%)
• Gaps: 31/261 - (11%)

  Fly   118 NAPDGIPRIYHLGTCGGRYN--AMVLELLGLSLEDL--FNICARK-FSLKTVLMIAKQLLHRIEY 177
            ||....|.|.:|...|.:.|  .||:.|||.:|:||  .|....| ||..|...:..|.::.::|
 Worm    10 NANGPAPHIPNLNLYGKKMNFSYMVMTLLGRNLQDLESTNFVVNKGFSRGTWSRVGIQWVYALKY 74

  Fly   178 VHSRHLIYRDVKPENFLIG-RTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHK--------- 232
            ||....|:|:|..:|..:| ...::|.|||||:||||.:.:    ...|.  ||:|
 Worm    75 VHYNGFIHRNVNTQNLFLGNEKDSERAKIIHILDFGLGRPF----ARYHA--RENKWIVRIARHS 133

  Fly   233 -SLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRG-SLPWQGLKADTLKERYQKIGDTKRA 295
             ...|:.||.|.|.|:.:||.|.||:.:|.::.:....| :||||   .|..:.|.:::  ....
 Worm   134 AEFRGSFRYASPNVHLRKEQGRVDDVWSLPYVIIELNGGKALPWQ---TDYRRGRVEQM--KLNL 193

  Fly   296 TPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTGK--TMST 358
            ||.:|:.| .|......:.::..|::::.||...:.:.|..:.:.:..|...:|||..:  .||.
 Worm   194 TPKDVMSD-MPACMDKLMPHLASLNYYQRPDDHMIFKCFWQVMENEKITPSSKFDWENEEPDMSV 257

  Fly   359 P 359
            |
 Worm   258 P 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	75/252 (30%)
		CK1gamma_C	354..439	CDD:463640	3/8 (38%)
ttbk-6	NP_498080.1	Protein Kinases, catalytic domain	1..231	CDD:473864	70/232 (30%)