DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and C03C10.2

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_497820.2	Gene:	C03C10.2 / 182156	WormBaseID:	WBGene00007269	Length:	341	Species:	Caenorhabditis elegans

Alignment Length:	307	Identity:	82/307 - (26%)
Similarity:	146/307 - (47%)	Gaps:	54/307 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 IGCGNFGELRLGKNLYNNEHVAIKMEPMKSKA----PQLHLEYR-FYKLLG-SHADNAPDGIPRI 126
            ||.|.:|::.:..::..|:..|:|:|| |.:|    .::.:|.: ..|:.| :|       ||.:
Worm    56 IGNGGYGQIFMVMDVKKNDERAMKIEP-KLRAEVITKRMIMEQQVLMKMQGKTH-------IPTM 112

  Fly   127 YHLGTCGGRYNAMVLELLGLSLEDLFNICARK------FSLKTVLMIAKQLLHRIEYVHSRHLIY 185
            |..| ...::|.::::||.:::.|.     ||      .|.:||..||.|.|:.::.:|....::
Worm   113 YASG-FNDQFNFIIMQLLSMNVGDF-----RKRSPLGRLSKETVGRIAYQTLNALKDIHDMGYVH 171

  Fly   186 RDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGRE 250
            |||||.|...|..:..|. |::::||||.:.: ..::...||:|.:....||.||:|:..|...|
Worm   172 RDVKPANICFGVHAQNRH-ILYLLDFGLVRRF-KTESGVCIPWRINAGFKGTERYVSVRVHEKLE 234

  Fly   251 QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHP-EEFATYLR 314
            |:..||..::.:.....:.|.|||:.|      |...:|...|:... ||..:|.. ::.|:.|
Worm   235 QTPWDDAFSVLYTAYELVVGELPWRYL------EDIHEIHGVKKLMN-EVTKNGEMFKDIASIL- 291

  Fly   315 YVRRLDF----------FETPDYDFLRRLFQDLFDRKGYTDEGEFDW 351
                :||          .|.| |:.|....:.|:..|...:  .:||
Worm   292 ----VDFHKMILECDPVVELP-YEKLLECLKCLYSPKSLLE--PYDW 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	82/307 (27%)
		S_TKc	62..335	CDD:214567	78/289 (27%)
		CK1gamma_C	354..428	CDD:289378
C03C10.2	NP_497820.2	PKc_like	49..317	CDD:304357	78/289 (27%)
C03C10.2	NP_497820.2	Pkinase	50..303	CDD:278497	74/274 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740