Protein Alignment gish and C05C12.1

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_502112.1
• Gene: C05C12.1 / 178032
• WormBaseID: WBGene00007335
• Length: 405
• Species: Caenorhabditis elegans
• Alignment Length: 422
• Identity: 97/422 - (22%)
• Similarity: 171/422 - (40%)
• Gaps: 115/422 - (27%)

  Fly    62 FRVGKKIGCGNFGEL-RLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGI-- 123
            ::|.:.||.|.:|:: ::.||.   :..|:|:||                   :..|..|..|
 Worm    25 YQVVESIGEGAYGQVFKVSKNA---KKYAMKVEP-------------------NRLDGGPASITK 67

  Fly   124 ------------PRIYHLGTCGGR---YNAMVLELLGLSLEDL-FNICARKFSLK-TVLMIAKQL 171
                        .:.:.:...|||   ::.:|:.|||.:|:.| ...|..|.... |...|..|.
 Worm    68 EIEVMMELNNRGAKFFPIFETGGREPKFHMVVMTLLGENLQVLRMKGCNPKACTPGTWSRIGIQC 132

  Fly   172 LHRIEYVHSRHLIYRDVKPENFLIGRTSTKRE-KIIHIIDFGLAKEYIDLDTNRHI--------- 226
            |..::.:|...:::.|:||.||:.|::..... ::.::||||:::::|     ||:
 Worm   133 LFVVKQMHDCGILHHDLKPTNFVWGQSDEALTCRVFYLIDFGISRKFI-----RHVKGTPINQQN 192

  Fly   227 --PYREHK----SLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKER 285
              .:|..|    ||.||.:|.|...|...:..|.|||.:|.:|....:: .|||:.|:|..|:
 Worm   193 GFEFRTEKKKVHSLVGTPKYTSPKAHAMADLGRGDDLWSLMYMIAELVK-PLPWEILEAKMLE-- 254

  Fly   286 YQKIGDTKRATPIE--VLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGE 348
                 :||..:.::  ...||    |......:....|...|:|:.:...|:::|::.|.:....
 Worm   255 -----NTKLKSKLKDHFGMDG----FGKIETMLHACTFNSFPNYEMIYLAFKEVFNKSGVSWLDP 310

  Fly   349 FDWTGKTMSTPVGSLQTGHEVIISPNKDRHNVTAKTNAKGGVAAW--PDV-----PKPGATL--- 403
            :||.||.|                |:..|....|:....  :.||  |||     ..|..|:
 Worm   311 YDWEGKNM----------------PSYKRWRQHAEKQRP--LFAWEQPDVGSYFRKDPFTTVQNA 357

  Fly   404 ---GNLTPADRHG-------SVQVVSSTNGEL 425
               |..|...:||       :|:.....||.:
 Worm   358 NVTGKTTKKKKHGKETTDETTVETCEEINGSV 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	77/329 (23%)
		CK1gamma_C	354..439	CDD:463640	19/92 (21%)
C05C12.1	NP_502112.1	Protein Kinases, catalytic domain	25..293	CDD:473864	72/306 (24%)