DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and ZK596.2

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_502028.1	Gene:	ZK596.2 / 177983	WormBaseID:	WBGene00014007	Length:	305	Species:	Caenorhabditis elegans

Alignment Length:	308	Identity:	91/308 - (29%)
Similarity:	149/308 - (48%)	Gaps:	48/308 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 KKIGCGNFGELRL--GKNLYNNEHVAIKMEP-------MKSKAPQLHLEYRFYKLLGSH----AD 117
            ||:|.|.||.:.|  .|.....|: |:|:|.       :|.:...| ||.:..|::|.|    ||
Worm    23 KKLGEGAFGAVYLVSQKEKPKVEY-ALKVEAESDPLGLLKMEVAVL-LEVKKQKIVGRHFLELAD 85

  Fly   118 NAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDL-----FNICARKFSLKTVLMIAKQLLHRIEY 177
            .           |....::|.||:.|:|.||:||     ||    |||:.|.:.:|:|.|..:|.
Worm    86 R-----------GNLPQKFNYMVMTLVGKSLQDLRKTAPFN----KFSMGTAISVARQSLEAVED 135

  Fly   178 VHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMS 242
            :|:...::||:||.|:.|||......:.::::|||:|:::...|.....| |......||.:|..
Worm   136 LHNIGFLHRDIKPGNYTIGRKEMHELRKVYMLDFGMARKFAREDGTLRNP-RARAGFRGTVKYAP 199

  Fly   243 INTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK---RATPIEVLCDG 304
            :..|:.|||.|:||:|:..:|.:....|.|||:.|...      ..:|..|   :.|.:..|..|
Worm   200 LACHIQREQCRKDDIESWLYMVVEMTCGRLPWRNLTES------DDVGVFKKECKTTRLRCLFGG 258

  Fly   305 HPEEFATYLRYVRRLDFFETPDYDFLRRLFQD-LFDRKGYTDEGEFDW 351
            .|.||......:.:..||:.|:|..:..|.:. :.:.|  ::|..:||
Worm   259 CPREFTEVFPILDKGKFFDAPEYTTIYELLEKAMVNTK--SNEFPYDW 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	91/308 (30%)
		S_TKc	62..335	CDD:214567	87/289 (30%)
		CK1gamma_C	354..428	CDD:289378
ZK596.2	NP_502028.1	STKc_TTBK	18..289	CDD:270919	87/289 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160785
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740