DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and kin-19

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001369852.1	Gene:	kin-19 / 175524	WormBaseID:	WBGene00002202	Length:	341	Species:	Caenorhabditis elegans

Alignment Length:	298	Identity:	154/298 - (51%)
Similarity:	207/298 - (69%)	Gaps:	12/298 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 MVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPD 121
            :|...:::.:|||.|:||::.:..|:.|.|.||||:|..:::.|||..|.:.|::|....
Worm    11 IVATKYKLIRKIGSGSFGDIYVSINVTNGEEVAIKLESNRARHPQLLYESKVYRILQGGV----- 70

  Fly   122 GIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYR 186
            |||.|...|| ...||.:|::|||.|||||||.|:|:|::|||||:|.|::.||||||.::.|:|
Worm    71 GIPHIRWYGT-EREYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIGRIEYVHVKNFIHR 134

  Fly   187 DVKPENFL--IGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGR 249
            |:||:|||  |||...|    :.:|||||||:|.|..|..||||||.|:|||||||.|||.|:|.
Worm   135 DIKPDNFLMGIGRHCNK----LFLIDFGLAKKYRDSRTRTHIPYREDKNLTGTARYASINAHLGI 195

  Fly   250 EQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLR 314
            |||||||:|:||::.|||.||:||||||||.|.|::|:||.:.|..|.:|.||.|.|.||..||.
Worm   196 EQSRRDDMESLGYVLMYFNRGTLPWQGLKAATKKQKYEKISEKKMTTSVEHLCKGFPAEFPMYLS 260

  Fly   315 YVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWT 352
            |.|.|.|.|:|||.:||:||:.||....:..:..||||
Worm   261 YTRGLRFDESPDYMYLRQLFRILFRTLNHQYDYTFDWT 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	153/294 (52%)
		S_TKc	62..335	CDD:214567	146/274 (53%)
		CK1gamma_C	354..428	CDD:289378
kin-19	NP_001369852.1	STKc_CK1_alpha	15..280	CDD:271030	145/274 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810