DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and Y39G8C.2

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_496946.1	Gene:	Y39G8C.2 / 175061	WormBaseID:	WBGene00012731	Length:	276	Species:	Caenorhabditis elegans

Alignment Length:	272	Identity:	88/272 - (32%)
Similarity:	133/272 - (48%)	Gaps:	36/272 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPM--KSKAPQLHLEYRFYKLLGS--HADNAPD 121
            |:.|.:.:|.|.||.:.|.|:...|:..|:|:|..  |.|..:|.:|....||:|:  |.....|
Worm    23 NYVVSRLLGEGGFGAVYLVKDTKTNKTFAMKVEQKMEKRKHSKLKMEIAILKLVGAGKHFTQIVD 87

  Fly   122 GIPRIYHLGTCGGR-----YNAMVLELLGLSLEDLFNICA-RKFSLKTVLMIAKQLLHRIEYVHS 180
                       .|:     |..:|:||:|.||.||.|..| |.||..|.|.:|.|.|..:|.:|.
Worm    88 -----------RGKKDKEGYFFLVMELVGKSLGDLKNERAERVFSFGTGLGVASQCLEAVEDLHR 141

  Fly   181 RHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINT 245
            ...|:||:||:|:..| ...||.. |:|:|||:|::|::.......| ||.....||.|:..:..
Worm   142 TGFIHRDLKPQNYACG-LDEKRHN-IYILDFGIARKYLNTKNELKTP-REAVGFKGTVRFAPLAC 203

  Fly   246 HMGREQSRRDDLEALGHMFMYFL--RGSLPWQGL--KADTLKERYQKIGDTKRATPIEVLCDG-- 304
            |...|...|||.|:..::.:..:  || |||:.:  |.:.|||: ::....||    :.|..|
Worm   204 HRFTELGPRDDCESWFYLLLDLILPRG-LPWRKMNEKGEVLKEK-EECRKEKR----DKLFYGIK 262

  Fly   305 HPEEFATYLRYV 316
            |..|....|.|:
Worm   263 HASELNKILDYI 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	88/272 (32%)
		S_TKc	62..335	CDD:214567	87/271 (32%)
		CK1gamma_C	354..428	CDD:289378
Y39G8C.2	NP_496946.1	PKc_like	23..276	CDD:389743	88/272 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740