DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and F59A6.4

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_494922.2	Gene:	F59A6.4 / 173865	WormBaseID:	WBGene00019086	Length:	762	Species:	Caenorhabditis elegans

Alignment Length:	347	Identity:	87/347 - (25%)
Similarity:	141/347 - (40%)	Gaps:	69/347 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TRQSVSTTTGVLMVG--PNFRVGKKIGCGNFGELRLGKNLYN--------NEHVAIKMEPMKSKA 99
            ||:.::....:|.||  ..::|...:|.|.||:      :|.        .:..|:|.|..:.:.
Worm   425 TRKKLAKGDVILGVGATDGWKVINLLGSGGFGD------VYKVHRESQPITKCYALKTESEEGEK 483

  Fly   100 PQLHLEYR---FYKLLGSHADNAPDGIPRIYHLGTCGG-RYNAMVLELLGLSLEDLFNICARK-- 158
            ..|.|:..   ..|......:|...........|.|.. :...:|:.|:|.||||:    .||
Worm   484 RYLRLKIEVTVMMKTAEKKKENKFKNFIEFVDRGKCEQLKCKYVVMGLVGPSLEDI----RRKYL 544

  Fly   159 ---FSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDL 220
               ||..|...:|.|.:..::.:||...::||:||.|:.:|...  ||..::::|||:||.|:|
Worm   545 LGSFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGLED--REDTVYMLDFGIAKLYVD- 606

  Fly   221 DTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGS--LPWQGLKADTLK 283
            :...|...|:.....||.||......|.:||.|:||||...::....:..|  :||:.|
Worm   607 ENGEHKVKRKKVKFLGTLRYACRACMMQQEQGRKDDLETWIYLVFDLMDESHGMPWRSL------ 665

  Fly   284 ERYQKIGDTKRATPIEVLCDGHPEEFAT----------------YLRYVRRLDFFETPDYDFLRR 332
                       .:|.|:|  ....||.|                .:.||..:.:..|||||::..
Worm   666 -----------CSPKEIL--KSKNEFFTNFDSSSVSATLKRLKGLVSYVDNMQYETTPDYDYIIN 717

  Fly   333 LFQDLFDRKGYTDEGEFDWTGK 354
            ..:......|.....:.||.||
Worm   718 FLKTTATEAGAKISKKLDWIGK 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	80/327 (24%)
		S_TKc	62..335	CDD:214567	77/307 (25%)
		CK1gamma_C	354..428	CDD:289378	1/1 (100%)
F59A6.4	NP_494922.2	PKc_like	120..372	CDD:304357
		SPS1	121..>274	CDD:223589
		SPS1	443..>627	CDD:223589	51/196 (26%)
		PKc_like	444..720	CDD:304357	77/307 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740