DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and T05A7.6

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_494824.1	Gene:	T05A7.6 / 173804	WormBaseID:	WBGene00020223	Length:	758	Species:	Caenorhabditis elegans

Alignment Length:	345	Identity:	90/345 - (26%)
Similarity:	143/345 - (41%)	Gaps:	67/345 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RQSVSTTTGVLMVG--PNFRVGKKIGCGNFGELRL--GKNLYNNEHVAIKMEPMKSKAPQLHLEY 106
            |:.:|:...:|.||  ..::|...:|.|.||::..  .::..:|:..|:|.|..:.:...|.|:.
Worm   422 RKKLSSGDVILGVGATDGWKVVNLLGSGGFGDVYKVHRESQASNKCYALKTESEEGEKRYLRLKV 486

  Fly   107 R---FYKLLGSHADNAPDGIPRIYHLGTCGG-RYNAMVLELLGLSLEDLFNICARK-----FSLK 162
            .   ..|......||...........|.|.. :...:|:.|:|.||||:    .||     ||..
Worm   487 EVTVMMKTAEKKKDNKFKNFIEFVDRGKCEQLKCKFVVMGLVGPSLEDI----RRKYLLASFSKH 547

  Fly   163 TVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIP 227
            |...:|.|.:..:..:||...::||:||.|:.:|  ..:||..::::|||:||.|:| :...|..
Worm   548 TSFNVAIQTVTALRDLHSLGYLHRDIKPANYAVG--LDEREDTVYMLDFGIAKLYVD-ENGVHKI 609

  Fly   228 YREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDT 292
            .|:.....||.||......|.:||.|:||||.              |..|..|.:.|.:
Worm   610 KRKKVKFLGTLRYACRACMMQQEQGRKDDLET--------------WIYLVFDLMDEAH------ 654

  Fly   293 KRATPIEVLCDGHPEE--------FATY---------------LRYVRRLDFFETPDYDFLRRLF 334
              ..|...|||  |.|        |||:               :.||..:.:..||||.::....
Worm   655 --GMPWRALCD--PREILKSKNTFFATFDNFQFSNILKRLKDLVVYVDDMQYDTTPDYSYILNFL 715

  Fly   335 QDLFDRKGYTDEGEFDWTGK 354
            :...:..|.....:.||.||
Worm   716 KTTANDVGAKITKKLDWMGK 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	83/326 (25%)
		S_TKc	62..335	CDD:214567	80/306 (26%)
		CK1gamma_C	354..428	CDD:289378	1/1 (100%)
T05A7.6	NP_494824.1	SPS1	100..>321	CDD:223589
		PKc_like	116..368	CDD:304357
		SPS1	439..>623	CDD:223589	52/190 (27%)
		PKc_like	440..716	CDD:304357	80/306 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740